1887

Abstract

Summary

The susceptibility of human leukocyte (α), fibroblast (β) and recombinant α-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant α-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that α-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human β-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.

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/content/journal/jgv/10.1099/0022-1317-60-2-397
1982-06-01
2020-01-22
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-60-2-397
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