We have previously shown that adult C57BL/6 mice are relatively resistant to intraperitoneal (i.p.) infection with herpes simplex virus type 1 (HSV-1). Here we show that newborn mice of the strain C57BL/6 are highly susceptible to i.p. infection with HSV-1. Newborn C57BL/6 mice, in contrast to adult mice, did not develop natural killer cell activity in the peritoneal cavity 24 h after i.p. injection of HSV-1, and showed only minimal titres of interferon in the peritoneal fluid after 4 h. After 24 h the peritoneal fluid of newborn mice contained high amounts of interferon and high titres of HSV-1. In contrast, the virus titres in the peritoneal cavity of adult mice were significantly lower. It is suggested that the early titres of interferon at the infection site that are observed in adult, resistant C57BL/6 mice but not in susceptible, newborn mice play a decisive role in resistance.
ArmerdingD.,
RossiterH.1981; Induction of natural killer cells by herpes simplex virus type 2 in resistant and sensitive inbred mouse strains. Immunobiology 158:369
BeckJ.,
EnglerH.,
BrunnerH.,
KirchnerH.1980; Interferon production in cocultures between mouse spleen cells and tumor cells. Possible role of mycoplasmas in interferon induction. Journal of Immunological Methods 38:63–73
EnglerH.,
ZawatzkyR.,
GoldbachA.,
SchroderC. H.,
WeyandC.,
HammerlingG. J.,
KirchnerH.1981; Experimental infection of inbred mice with herpes simplex virus. II. Interferon production and activation of natural killer cells in the peritoneal exudate. Journal of General Virology 55:25–30
GidlundN.,
OernA.,
WigzellH.,
SenikA.,
GresserI.1978; Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature, London 273:759–761
GresserI.,
ToveyM. G.,
MauryC.,
BanduM. T.1976; Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis virus, Newcastle disease and influenza viruses. Journal of Experimental Medicine 144:1316–1323
KirchnerH.,
HirtH. M.,
KleinickeC.,
MunkK.1976; Replication of herpes simplex virus in mouse spleen cell cultures stimulated by lipopolysaccharide. Journal of Immunology 117:1753–1756
KirchnerH.,
KochenM.,
HirtH. M.,
MunkK.1978; Immunological studies of HSV infection of resistant and susceptible inbred strains of mice. Zeitschrift fur Immunitdtsforschung und experimentelle Therapie 154:147–154
KirchnerH.,
ZawatzkyR.,
EnglerH.,
SchroderC. H.1980; Studies of resistance of mice against herpes simplex virus. In Genetic Control of Natural Resistance to Infection and Malignancy pp 267–276 Edited by
SkameneE.,
KongshavnP. A. L.,
LandyM.
New York & London: Academic Press;
LopezC.1978; Immunological nature of genetic resistance of mice to herpes simplex virus type-1 infection. In Oncogenesis and Herpesviruses vol 3: pp 775–781 Edited by
de TheG.,
HenleW.,
RappF.
IARC Scientific Publications; 24
SchröderC. H.,
EnglerH.,
KirchnerH.1981; Protection of mice by an apathogenic strain of HSV-1 against lethal infection by a pathogenic strain. Journal of General Virology 52:159–161
ZawatzkyR.,
HilfenhausJ.,
KirchnerH.1979; Resistance of nude mice to herpes simplex virus and correlation with in vitro production of interferon. Cellular Immunology 47:424–428
ZawatzkyR.,
HilfenhausJ.,
MarcucciF.,
KirchnerH.1981; Experimental infection of inbred mice with herpes simplex virus. I. Investigation of humoral and cellular immunity and of interferon induction. Journal of General Virology 53:31–38
ZawatzkyR.,
GresserI.,
De MaeyerE.,
KirchnerH.1982; Role of interferon in the resistance of C57BL/6 mice to different doses of herpes simplex virus type 1. Journal of Infectious Diseases (in press)