1887

Abstract

Summary

The physiological defects associated with 17 temperature-sensitive mutants of the 3/57 strain of foot-and-mouth disease virus were examined in terms of the ability of the mutants to produce infective RNA and complementfixing antigen under restrictive conditions. The yields of infective RNA obtained with different mutants ranged from less than 0·31 to 87% of normal, and of complement-fixing antigen from 12·6 to 99·6 % of normal. Genetic recombination was observed in crosses of mutants with different physiological effects, such that the mutants could be arranged in five groups.

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/content/journal/jgv/10.1099/0022-1317-6-2-213
1970-02-01
2023-01-28
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References

  1. Arlinghaus R. B., Polatnick J., Vande Woude G. F. 1966; Studies on foot-and-mouth disease virus ribonucleic acid synthesis. Virology 30:541
    [Google Scholar]
  2. Bachrach H. L. 1966; Ribonucleic acid of foot-and-mouth disease virus: An ultrasensitive plaque assay. Proceedings of the Society for Experimental Biology and Medicine 123:939
    [Google Scholar]
  3. Brooksby J. B. 1952; The technique of complement fixation in foot-and-mouth disease research. A.R.C. Report Series12 London: H.M.S.O.;
    [Google Scholar]
  4. Cooper P. D. 1967; Genetic analysis of animal viruses. British Medical Bulletin 23:155
    [Google Scholar]
  5. Cooper P. D. 1968; A genetic map of poliovirus temperature-sensitive mutants. Virology 35:584
    [Google Scholar]
  6. Cooper P. D., Johnson R. T., Garwes D. J. 1966; Physiological characterisation of heat de-fective (temperature-sensitive) poliovirus mutants: preliminary classification. Virology 30:638
    [Google Scholar]
  7. Cooper P. D., Stoker M. G. P. 1962; Polyoma transformation of hamster cell clones-an investigation of genetic factors affecting cell competence. Virology 16:147
    [Google Scholar]
  8. Polatnlck J., Arlinghaus R. B. 1967; Foot-and-mouth disease virus induced ribonucleic acid polymerase in baby hamster kidney cells. Virology 31:601
    [Google Scholar]
  9. Pringle C. R. 1968; Recombination between conditional lethal mutants within a strain of foot-and- mouth disease virus. Journal of General Virology 2:199
    [Google Scholar]
  10. Pringle C. R. 1969; Electrophoretic properties of foot-and-mouth disease virus strains and the selection of intra-strain mutants. Journal of General Virology 4:541
    [Google Scholar]
  11. Pringle C. R., Slade W. R. 1968; The origin of hybrid variants derived from subtype strains of foot-and-mouth disease virus. Journal of General Virology 2:319
    [Google Scholar]
  12. Tan K. B., Sambrook J. F., Bellett A. J. D. 1969; Semliki Forest virus temperature-sensitive mutants: isolation and characterisation. Virology 38:427
    [Google Scholar]
  13. Wentworth B. B., Mccahon D., Cooper P. D. 1968; Production of infectious RNA and serum-blocking antigen by poliovirus temperature-sensitive mutants. Journal of General Virology 2:297
    [Google Scholar]
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