1887

Abstract

Summary

The physiological defects associated with 17 temperature-sensitive mutants of the 3/57 strain of foot-and-mouth disease virus were examined in terms of the ability of the mutants to produce infective RNA and complement-fixing antigen under restrictive conditions. The yields of infective RNA obtained with different mutants ranged from less than 0.31 to 87% of normal, and of complement-fixing antigen from 12.6 to 99.6% of normal. Genetic recombination was observed in crosses of mutants with different physiological effects, such that the mutants could be arranged in five groups.

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/content/journal/jgv/10.1099/0022-1317-6-2-213
1970-02-01
2019-11-19
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-6-2-213
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