Interferon Production by Myxoviruses in Chick Embryo Cells Free

Abstract

SUMMARY

Both fowl plague and Newcastle disease viruses failed to produce interferon in chick-embryo cells because of the inhibitory effect of infection on host-cell protein synthesis. When this inhibitory effect was destroyed by ultraviolet irradiation or by hydroxylamine inactivation, interferon was formed. No virus RNA synthesis could be detected in the interferon-producing cells and it was concluded that the virus single-stranded RN A was the stimulus for interferon formation.

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1970-01-01
2024-03-28
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