1887

Abstract

SUMMARY

Both fowl plague and Newcastle disease viruses failed to produce interferon in chick-embryo cells because of the inhibitory effect of infection on host-cell protein synthesis. When this inhibitory effect was destroyed by ultraviolet irradiation or by hydroxylamine inactivation, interferon was formed. No virus RNA synthesis could be detected in the interferon-producing cells and it was concluded that the virus single-stranded RN A was the stimulus for interferon formation.

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1970-01-01
2022-01-25
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References

  1. Barry R. D., Davies P. 1968; The sedimentation of influenza virus and its RNA in sucrose density gradients. Journal of General Virology 2:59
    [Google Scholar]
  2. Bratt M. A., Robinson W. S. 1967; Ribonucleic acid synthesis in cells infected with Newcastle Disease virus. Journal of Molecular Biology 23:1
    [Google Scholar]
  3. Burke D. C. 1966; The production of interferons by viruses: mechanisms. In Interferons p. 55 Finter N. B. Ed. by Amsterdam: North Holland Publishing Co;
    [Google Scholar]
  4. Burke D. C., Isaacs A. 1958; Some factors affecting the production of interferon. British Journal of Experimental Pathology 39:452
    [Google Scholar]
  5. Cartwright K. L., Burke D. C. 1970; Viral nucleic acids formed in chick embryo cells infected with Semliki Forest virus. Journal of General Virology 6: In the press
    [Google Scholar]
  6. Duesberg P. H. 1968a; The RNA’s of influenza virus. Proceedings of the National Academy of Sciences U.S.A 59:930
    [Google Scholar]
  7. Duesberg P. H. 1968b; Physical properties of Rous sarcoma RNA. Proceedings of the National Academy of Sciences U.S.A 60:1511
    [Google Scholar]
  8. Duesberg P. H., Robinson W. S. 1967; On the structure and replication of influenza virus. Journal of Molecular Biology 25:383
    [Google Scholar]
  9. Field A. K., Tytell A. A., Lampson G. P., Hilleman M. R. 1967a; Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes. Proceedings of the National Academy of Sciences U.S.A 58:1004
    [Google Scholar]
  10. Field A. K., Lampson G. P., Tytell A. A., Nemes M. M., Hilleman M. R. 1967b; Inducers of interferon and host resistance, IV. Double-stranded replicative form RNA (MS2-RF-RNA) from E. coli infected with MS 2 coliphage. Proceedings of the National Academy of Sciences U.S.A 58:2102
    [Google Scholar]
  11. Finkelstein M. S., Bausek G. H., Merigan T. C. 1968; Interferon inducers in vitro: difference in sensitivity to inhibitors of RNA and protein synthesis. Science; New York: 161465
    [Google Scholar]
  12. Ho M., Breinig M. K. 1965; Metabolic determinants of interferon formation. Virology 25:331
    [Google Scholar]
  13. Ho M., Fantes K. H., Burke D. C., Finter N. B. 1966; Interferons or interferon-like inhibitors induced by non-viral substances. In Interferons p. 181 Finter N. B. Ed. by Amsterdam North Holland Publishing Co;
    [Google Scholar]
  14. Lampson G. P., Tytell A. A., Field A. K., Nemes M. M., Hilleman M. R. 1967; Inducers of interferon and host resistance, I. Double-stranded RNA from extracts of Penicillium funiculosum . Proceedings of the National Academy of Sciences U.S.A 58:782
    [Google Scholar]
  15. Long W. F., Burke D. C. 1970; The effect of infection with fowl plague virus on protein synthesis in chick embryo cells. Journal of General Virology 6:1
    [Google Scholar]
  16. Miller P. A., Milstrey K. P., Trown P. W. 1968; Specific inhibition of viral ribonucleic acid replication by gliotoxin. Science; New York: 159431
    [Google Scholar]
  17. Pons M. W., Hirst G. K. 1968; Polyacrylamide gel electrophoresis of the replicative form of influenza virus RNA. Virology 35:182
    [Google Scholar]
  18. Scholtissek C. 1965; Biochemische Studien zur Vermehrung der Myxoviren. Zentralblatt für Veterinärmedizin 12b:351
    [Google Scholar]
  19. Scholtissek C., Rott R. 1964; Behaviour of virus-specific activities in tissue culture infected with myxoviruses after chemical changes of the viral ribonucleic acid. Virology 22:169
    [Google Scholar]
  20. Scholtissek C., Rott R. 1969; Effect of temperature on the multiplication of an influenza virus. Journal of General Virology 5:283
    [Google Scholar]
  21. Skehel J. J., Burke D. C. 1968a; Interferon production by Semliki Forest virus inactivated with hydroxylamine. Journal of General Virology 3:35
    [Google Scholar]
  22. Skehel J. J., Burke D. C. 1968b; A temperature-sensitive event in interferon formation. Journal of General Virology 3:191
    [Google Scholar]
  23. Skehel J. J., Burke D. C. 1969; Ribonucleic acid synthesis in chick embryo cells infected with fowl plague virus. Journal of Virology 3:429
    [Google Scholar]
  24. Skehel J. J., Hay A. J., Burke D. C., Cartwright L. N. 1967; Effects of actinomycin D and 2-mercapto-1-(β4-pyridethyl) benzimidazole on the incorporation of [3H]-uridine by chick embryo cells. Biochimica et Biophysica Acta 142:430
    [Google Scholar]
  25. Trown P. W. 1968; Antiviral activity of N,N′-dimcthyl-epidithiapiperazinedione, a synthetic compound related to the gliotoxins, LL-S88α and β, chetomin and the sporidesmins. Biochemical and Biophysical Research Communications 33:402
    [Google Scholar]
  26. Tytell A. A., Lampson G. P., Field A. K., Hilleman M. R. 1967; Inducers of interferon and host resistance. III. Double-stranded RNA fromreovirus type 3 virions (Reo 3-RNA). Proceedings of the National Academy of Sciences U.S.A 59:1719
    [Google Scholar]
  27. Walters S., Burke D. C., Skehel J. J. 1967; Interferon production and RNA inhibitors. Journal of General Virology 1:349
    [Google Scholar]
  28. Youngner J. S., Scott A. W., Hallum J. V., Stinebring W. R. 1966; Interferon production by inactivated Newcastle Disease virus in cell cultures and in mice. Journal of Bacteriology 92:862
    [Google Scholar]
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