1887

Abstract

SUMMARY

Retinal cultures from newborn rabbits were infected with herpes simplex virus and neuro- and non-neuroadapted strains of vaccinia virus. Herpes simplex virus gave rise to characteristic nuclear changes of mesenchymal cells, and rod cells and a rapid destruction of neurons. The vaccinia virus strains all caused development of cytoplasmic inclusion bodies in the mesenchymal cells, which then degenerated. Changes in neuroectodermal cells were observed relatively late and might be secondary to the deterioration of mesenchymal cells. The implication of these findings for the study of the problem of selective cellular susceptility of the central nervous system to viruses is discussed.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-6-1-41
1970-01-01
2024-10-04
Loading full text...

Full text loading...

/deliver/fulltext/jgv/6/1/JV0060010041.html?itemId=/content/journal/jgv/10.1099/0022-1317-6-1-41&mimeType=html&fmt=ahah

References

  1. Bodian D. 1964; An electron microcopic study of the monkey spinal cord. III. Cytological effects of mild and virulent poliovirus infection. Bulletin Johns Hopkins Hospital 114:13
    [Google Scholar]
  2. Coffin D L., Liu C. 1957; Studies on canine distemper infection by means of fluorescein-labelled antibody. Virology 3:132
    [Google Scholar]
  3. Feldman L. A., Sheppard R. D., Bornstein M. B. 1968; Herpes simplex virus-host cell relationships in organized cultures of mammalian nerve tissues. Journal of Virology 2:621
    [Google Scholar]
  4. Fernandes M. V., Pomerat C. M. 1961; Cytopathogenic effects of rabies virus on nervous tissue in vitro . Zeitschrift für Zellforschung und Mikroscopische Anatomie 53:431
    [Google Scholar]
  5. Hamashima Y., Kyogoka M., Hiramatsu S., Nakashima Y., Yamauchi R. 1959; Immuno-cytological studies employing labelled active protein. III. Encephalitis Japonica. Acta Pathologica Japonica 9:89
    [Google Scholar]
  6. Hansson H.-A. 1965; A tissue culture study of inherited dystrophy of the retina in mice. Virchows Archiv für pathologische Anatomie und Physiologie und für Klinische Medizin 340:69
    [Google Scholar]
  7. Hansson H.-A. 1966a; Selective effects of metabolic inhibitors on retinal cultures. Experimental Eye Research 5:335
    [Google Scholar]
  8. Hansson H.-A. 1966b; The distribution of acetylcholine esterase and other hydrolytic enzymes in retinal cultures. Acta Physiologica Scandinavica 70: suppl 288
    [Google Scholar]
  9. Hansson H.-A., Sourander P. 1964; Studies on cultures of mammalian retina. Zeitschrift für Zellforschung und Mikroscopische Anatomie 62:26
    [Google Scholar]
  10. Hild W., Callas G. 1967; The behavior of retinal tissue in vitro, light and electron microscopic observations. Zeitschrift für Zellforschung und Mikroscopische Anatomie 80:1
    [Google Scholar]
  11. Hogue M. J., Mcallister R., Greene A. E., Coriell L. I. 1955; The effect of poliomyelitis on human brain cells in tissue culture. Journal of Experimental Medicine 102:29
    [Google Scholar]
  12. Johnson R. T. 1964; The pathogenesis of herpes virus encephalitis. Journal of Experimental Medicine 119:343
    [Google Scholar]
  13. Johnson R. T. 1965; Experimental rabies. Studies of cellular vulnerability and pathogenesis using fluorescent antibody staining. Journal of Neuropathology and Experimental Neurology 24:662
    [Google Scholar]
  14. Johnson R. T., Mims C. A. 1968; Pathogenesis of viral infections of the nervous system. New England Journal of Medicine 278:84
    [Google Scholar]
  15. Kristensson K., Sourander P. 1969; Changes in vascular permeability of the central nervous system by experimental herpes simplex and vaccinia virus infection. Acta neuropathologica 14:38
    [Google Scholar]
  16. Kunin C. M. 1964; Cellular susceptibility to enteroviruses. Bacteriological Reviews 28:382
    [Google Scholar]
  17. Leestma J. E., Bornstein M. B., Sheppard R. D., Feldman L. A. 1969; Ultrastructural aspects of herpes simplex virus infection on organized cultures of mammalian nervous tissue. Laboratory Investigation 20:70
    [Google Scholar]
  18. Mannweiler K., Palacios O. 1969; Züchtung und Vermehrung von Herpes simplex Virus in Zellkultur vom Nervensystem. Acta neuropathologica 12:276
    [Google Scholar]
  19. Margolis G., Pickett J. P. 1956; New applications of the luxol fast blue myelin stain. Laboratory Investigation 5:459
    [Google Scholar]
  20. Olsson Y., Hansson H.-A., Sourander P. 1965; Mast cells in cultures from nervous tissue. Acta neuropathologica 5:307
    [Google Scholar]
  21. Storts R. W., Koestner A., Dennis R. A. 1968; The effect of canine distemper virus on explant tissue culture of canine cerebellum. Acta neuropathologica 11:1
    [Google Scholar]
  22. Yamamoto T., Otani S., Shiraki H. 1965; A study of the evolution of viral infection in experimental herpes simplex encephalitis and rabies by means of fluorescent antibody. Acta neuropathologica 5:288
    [Google Scholar]
  23. Yoshida J., Hotta S. 1966; Immunofluorescence of Japanese encephalitis virus infection in vitro: localization of viral antigen in canine cerebellar tissue cultures. Japanese Journal of Microbiology 10:183
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-6-1-41
Loading
/content/journal/jgv/10.1099/0022-1317-6-1-41
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error