1887

Abstract

SUMMARY

When chick embryo cells were infected with fowl plague virus, the rate of protein synthesis fell to 30 to 40% of controls by 8 hr after infection. This effect was prevented by ultraviolet irradiation of the virus, but more slowly than the capacity to produce infectious virus. The inhibition of protein synthesis was not delayed by incubation of the cells with 1 g./ml. of puro-mycin for 5 hr, but addition of 50 g./ml. of puromycin or cycloheximide delayed development of the inhibitory effect. No inhibition developed in cells which had been incubated with partially purified interferon before infection. Addition of -fluorophenylalanine did not affect the development of the inhibition, which was also unaffected by addition of actinomycin or by ultraviolet irradiation of the cells. The effect was thought to depend upon the synthesis of a virus-directed protein using the RNA of the infecting virus.

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1970-01-01
2024-04-19
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References

  1. Aminoff D. 1961; Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. Biochemical Journal 81:384
    [Google Scholar]
  2. Barry R. D. 1964; The effects of actinomycin D and ultraviolet irradiation on the production of fowl plague virus. Virology 24:563
    [Google Scholar]
  3. Barry R. D., Ives D. R., Cruickshank J. G. 1962; Participation of deoxyribonucleic acid in the multiplication of influenza virus. Nature; London: 1941139
    [Google Scholar]
  4. Bradstreet C. M. P., Taylor C. E. D. 1962; Techniques of complement fixation test applicable to the diagnosis of virus diseases. Monthly Bulletin of Ministry of Health & Public Health Laboratory Service 21:96
    [Google Scholar]
  5. Burke D. c., Morrison J. M. 1965; Interferon production in chick embryo cells. II. The role of DNA. Virology 27:108
    [Google Scholar]
  6. Fantes K. H. 1967; Purification of interferon from chick embryonic allantoic fluids and fibroblast tissue infected with influenza virus. Journal of General Virology 1:257
    [Google Scholar]
  7. Gandhi S. S., Burke D. C. 1970; Interferon production by myxoviruses in chick embryo cells. Journal of General Virology 6:95
    [Google Scholar]
  8. Graham E. R. B. 1961; Some aspects of the structure of the carbohydrate moiety of fetuin. Australian Journal of Science 24:140
    [Google Scholar]
  9. Hatchard C. G., Parker C. A. 1956; A new sensitive chemical actinometer. II. Potassium ferrioxa-late as a standard chemical actinometer. Proceedings of the Royal Society of London Series A 235:518
    [Google Scholar]
  10. Ho P. P. K., Walters C. P. 1966; Influenza virus-induced ribonucleic acid nucleotidyl transferase and the effect of actinomycin D of its formation. Biochemistry 5:231
    [Google Scholar]
  11. Kelly R. T., Greiff D. 1965; Neuraminidase and neuraminidase-labile substrates in experimental influenza virus encephalitis. Biochimica et Biophysica Acta 110:548
    [Google Scholar]
  12. Long W., Burke D. C. 1968; The effect of infection with fowl plague virus on protein synthesis in chick embryo cells. Biochemical Journal 110:41P
    [Google Scholar]
  13. Martin E. M., Kerr I. M. 1968 In The Molecular Biology of Viruses p. 15 Crawford L. V., Stoker M. G. P. Ed. by Cambridge University Press;
    [Google Scholar]
  14. Moss B. 1968; Inhibition of Hela cell protein synthesis by the vaccinia virion. Journal of Virology 2:1028
    [Google Scholar]
  15. Naftalin R. 1967; Effects on host-cell ribonucleic acid metabolism of encephalomyocarditis (EMC) virus exposed to ultraviolet irradiation. Biochemical Journal 105:51P
    [Google Scholar]
  16. Scholtissek C. 1965; Biochemische Studien zur Vermehrung der Myxoviren. Zentralblatt für Veterinärmedizin 126:351
    [Google Scholar]
  17. Scholtissek C., Rott R. 1969a; Ribonucleic acid nucleotidyl transferase induced in chick fibroblasts after infection with an influenza virus. Journal of General Virology 4:125
    [Google Scholar]
  18. Scholtissek C., Rott R. 1969b; Effect of temperature on the multiplication of an influenza virus. Journal of General Virology 5:283
    [Google Scholar]
  19. Scholtissek C., Becht H., Drzeniek R. 1967; Biochemical studies on the cytopathic effect of influenza viruses. Journal of General Virology 1:219
    [Google Scholar]
  20. Skehel J. J., Burke D. C. 1969; Ribonucleic acid synthesis in chick embryo cells infected with fowl plague virus. Journal of Virology 3:429
    [Google Scholar]
  21. Skehel J. J., Hay A. J., Burke D. C., Cartwright L. N. 1967; Effects of actinomycin D and 2-mercapto-1-(β-4-pyridethyl) benzimidazole on the incorporation of [3H]uridine by chigk embryo cells. Biochimica et Biophysica Acta 142:430
    [Google Scholar]
  22. Walters S., Burke D. C., Skehel J. J. 1967; Interferon production and RNA inhibitors. Journal of General Virology 1:349
    [Google Scholar]
  23. White D. O., Cheyne I. M. 1966; Early events in the eclipse phase of influenza and parainfluenza virus infection. Virology 29:49
    [Google Scholar]
  24. White D. O., Day H. M., Batchelder E. J., Cheyne I. M., Wansbrough A. J. 1965; Delay in the multiplication of influenza virus. Virology 25:289
    [Google Scholar]
  25. Willems M., Penman S. 1966; The mechanism of host-cell protein synthesis inhibition by poliovirus. Virology 30:355
    [Google Scholar]
  26. Wilson D. E. 1968; Inhibition of host-cell protein and ribonucleic acid synthesis by Newcastle disease virus. Journal of Virology 2:1
    [Google Scholar]
  27. Zimmermann T., Schäfer W. 1960; Effect of p-fluorophenylalanine on fowl plague virus multiplication. Virology 11:676
    [Google Scholar]
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