Inability to Transmit Scrapie by Transfection of Mouse Embryo Cells in vitro

References

1. Alper T., Haig D. A., Clarke M. C. 1966; The exceptionally small size of the scrapie agent. Biochemical and Biophysical Research Communications 22:278–284
   [Google Scholar]
2. Alper T., Cramp W. A., Haig D. A., Clarke M. C. 1967; Does the agent of scrapie replicate without nucleic acid?. Nature, London 214:764–767
   [Google Scholar]
3. Alper T., Haig D. A., Clarke M. C. 1978; The scrapie agent: evidence against its dependence for replication on intrinsic nucleic acid. Journal of General Virology 41:503–516
   [Google Scholar]
4. Blair D. G., Clewell D. B., Sheratt D. J., Helinski D. R. 1971; Strand-specific supercoiled DNA-protein relaxation complexes of the bacterial plasmids Col El and Col E2. Proceedings of the National Academy of Sciences of the United States of America 68:210–214
   [Google Scholar]
5. Clarke M. C. 1979; Infection of cell cultures with scrapie agent. In Slow Transmissible Diseases of the Nervous System vol 2: pp 225–242 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
   [Google Scholar]
6. Diener T. O. 1972; Is the scrapie agent a viroid?. Nature New Biology 235:218–219
   [Google Scholar]
7. Faust C. H. Jr, Diggelmann H., Macn B. 1973; Isolation of poly(adenylic acid)-rich ribonucleic acid from mouse myeloma and synthesis of complementary deoxyribonucleic acid. Biochemistry 12:925–931
   [Google Scholar]
8. Field E. J. 1966; Transmission experiments with multiple sclerosis: an interim report. British Medical Journal 2:564–565
   [Google Scholar]
9. Gibbons R. A., Hunter G. D. 1967; Nature of the scrapie agent. Nature, London 215:1041–1043
   [Google Scholar]
10. Gibbs C. J. Jr 1967; Search for infectious etiology in chronic and subacute degenerative diseases of the central nervous system. Current Topics in Microbiology and Immunology 40:44–48
    [Google Scholar]
11. Gibbs C. J. Jr, Gajdusek D. C., Muel B., Latarjet R. 1978; Unusual resistance to ionizing radiation of the viruses of kuru, Creutzfeldt-Jakob disease, and scrapie. Proceedings of the National Academy of Sciences of the United States of America 75:6268–6270
    [Google Scholar]
12. Graham F. L., Van Der Eb A. J. 1973; A new technique for the assay of infectivity of human adenovirus 5-DNA. Virology 52:456–467
    [Google Scholar]
13. Graham F. L., Veldhuisen G., Wilkie N. M. 1973; Infectious herpesvirus DNA. Nature New Biology 245:265–266
    [Google Scholar]
14. Haig D. A., Clarke M. C. 1965; Observations on the scrapie agent. In Slow, Latent and Temperate Virus Infections pp 215–219 Washington D.C.: U.S. Government Printing Office;
    [Google Scholar]
15. Hansen J. N. 1974; Isolation of higher molecular weight DNA from Bacillus cereus T using proteinase K. Preparative Biochemistry 4:473–488
    [Google Scholar]
16. Hunter G. D., Millson G. C. 1964; Studies on the heat stability and chromatographic behaviour of the scrapie agent. Journal of General Microbiology 37:251–258
    [Google Scholar]
17. Hunter G. D., Collis S. C., Millson G. C., Kimberlin R. H. 1976; Search for scrapie-specific RNA and attempts to detect an infectious DNA or RNA. Journal of General Virology 32:157–162
    [Google Scholar]
18. Kieff E. D., Bachenheimer S. L., Roizman B. 1971; Size, composition and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2. Journal of Virology 8:125–132
    [Google Scholar]
19. Kingsbury D. T., Smeltzer D. A., Gibbs C. J., Gajdusek D. C. 1981; Evidence for normal cell-mediated immunity in scrapie-infected mice. Infection and Immunity 32:1176–1180
    [Google Scholar]
20. Latarjet R. 1979; Inactivation of the agents of scrapie, Creutzfeldt-Jakob disease, and kuru by radiations. In Slow Transmissible Diseases of the Nervous System vol 2: pp 387–407 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
21. Lee Y. F., Nomoto A., Detjen B. H., Wimmer E. 1977; A protein covalently linked to poliovirus genome RNA. Proceedings of the National Academy of Sciences of the United States of America 74:59–63
    [Google Scholar]
22. Malone T. G., Marsh R. F., Hanson R. P., Semancik J. S. 1979; Evidence for the low molecular weight of scrapie agent. Nature, London 278:575–576
    [Google Scholar]
23. Marsh R. F., Semancik J. S., Medappa K. C., Hanson R. F., Rueckert R. R. 1974; Scrapie and transmissible mink encephalopathy: search for infectious nucleic acid. Journal of Virology 13:993–996
    [Google Scholar]
24. Millson G. C. 1965; Lysosomal enzymes in normal and scrapie mouse brain. Journal of Neurochemistry 12:461–468
    [Google Scholar]
25. Mould D. L., Dawson A. M. 1970; The response in mice to heat-treated scrapie agent. Journal of Comparative Pathology 80:595–600
    [Google Scholar]
26. Porter D. D., Porter H. G., Cox N. A. 1973; Failure to demonstrate a humoral immune response to scrapie infection in mice. Journal of Immunology 3:1407–1410
    [Google Scholar]
27. Prusiner S. B., Groth D. F., Cochran S. P., Marsiaz F. R., Mckinley M. P., Martinez H. M. 1980a; Molecular properties, partial purification and assay by incubation period measurements of the hamster scrapie agent. Biochemistry 19:4883–4891
    [Google Scholar]
28. Prusiner S. B., Groth D. F., Cochran S. P., McKinley M. P., Marsiarz F. R. 1980b; Gel electrophoresis and glass permeation chromatography of the hamster scrapie agent after enzymatic digestion and detergent extraction. Biochemistry 19:4892–4898
    [Google Scholar]
29. Ransom B. R., Neale E., Henkart M., Bullock P. N., Nelson P. G. 1977; Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties. Journal of Neurophysiology 40:1132–1150
    [Google Scholar]
30. Sheldrick P., Laithier M., Lando D., Ryhiner M. L. 1973; Infectious DNA from herpes simplex virus: infectivity of double-stranded and single-stranded molecules. Proceedings of the National Academy of Sciences of the United States of America 70:3621–3625
    [Google Scholar]
31. Stamp J. T., Brotherton J. G., Zlotnik L., Mackay J. M. K., Smith W. 1959; Further studies in scrapie. Journal of Comparative Pathology 69:268–280
    [Google Scholar]
32. Stow N. D., Wilkie N. M. 1976; An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA. Journal of General Virology 33:447–458
    [Google Scholar]
33. Ward R. L., Porter D. D., Stevens J. G. 1974; Nature of the scrapie agent: evidence against a viroid. Journal of Virology 14:1099–1103
    [Google Scholar]
34. Zasloff M., Ginder G. D., Felsenfeld G. 1978; A new method for the purification of covalently closed circular DNA molecules. Nucleic Acids Research 5:1139–1152
    [Google Scholar]