1887

Abstract

SUMMARY

Infection of CBA/J mice with low doses of strain WE lymphocytic choriomeningitis (LCM) virus resulted in high cell-mediated and relatively low humoral virus-specific immune phenomena; anamnestic responses were marked. In contrast, infection with high doses of this virus induced no or low degrees of cell-mediated immune phenomena but higher antibody concentrations. Subsequent challenge of these mice did not reveal cell-mediated immunity. However, transfer of spleen cells from mice suppressed as to cell-mediated immunity together with virus into X-irradiated recipients led to marked anamnestic responses. Furthermore, when spleen cells from mice previously infected with low virus doses were injected into mice previously infected with high virus doses, cell-mediated immune phenomena could not be induced by concomitantly inoculated virus, although in controls anamnestic responses were readily evoked. Thus, infection with high doses of LCM virus actively suppressed LCM virus-specific cell-mediated immune responses but led to increased production of antibodies. Suppressor cells could not be demonstrated.

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/content/journal/jgv/10.1099/0022-1317-58-2-223
1982-02-01
2022-01-29
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References

  1. Bengtson I. A., Wooley J. G. 1936; Cultivation of the virus of lymphocytic choriomeningitis in the developing chick embryo. Public Health Reports 51:29–41
    [Google Scholar]
  2. Buchmeier M. J., Welsh R. M., Dutko F. J., Oldstone M. B. A. 1980; The virology and immunobiology of lymphocytic choriomeningitis virus infection. Advances in Immunology 30:275–331
    [Google Scholar]
  3. Cairns H. J. F. 1950; Intracerebral inoculation of mice: fate of the inoculum. Nature, London 166:910–911
    [Google Scholar]
  4. Cihak J., Lehmann-Grube F. 1978; Immunological tolerance to lymphocytic choriomeningitis virus in neonatally infected virus carrier mice: evidence supporting a clonal inactivation mechanism. Immunology 34:265–275
    [Google Scholar]
  5. Doherty P. C., Zinkernagel R. M., Ramshaw I. A. 1974; Specificity and development of cytotoxic thymus-derived lymphocytes in lymphocytic choriomeningitis. Journal of Immunology 112:1548–1552
    [Google Scholar]
  6. Doyle M. V., Oldstone M. B. A. 1978; Interactions between viruses and iymphocytes. I. In vivo replication of lymphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections. Journal of Immunology 121:1262–1269
    [Google Scholar]
  7. Dunlop M. B. C., Blanden R. V. 1977; Mechanisms of suppression of cytotoxic T-cell responses in murine lymphocytic choriomeningitis virus infection. Journal of Experimental Medicine 145:1131–1143
    [Google Scholar]
  8. Gschwender H. H., Rutter G., Lehmann-Grube F. 1976; Lymphocytic choriomeningitis virus. II. Characterization of extractable complement-fixing activity. Medical Microbiology and Immunology 162:119–131
    [Google Scholar]
  9. Hotchin J. 1962; The foot pad reaction of mice to lymphocytic choriomeningitis virus. Virology 17:214–216
    [Google Scholar]
  10. Hotchin J., Benson L. 1963; The pathogenesis of lymphocytic choriomeningitis in mice: the effects of different inoculation routes and the footpad response. Journal of Immunology 91:460–468
    [Google Scholar]
  11. Julius M. H., Simpson E., Herzenberg L. A. 1973; A rapid method for the isolation of functional thymus-derived murine lymphocytes. European Journal of Immunology 3:645–649
    [Google Scholar]
  12. Kimmig W., Lehmann-Grube F. 1979; The immune response of the mouse to lymphocytic choriomeningitis virus. I. Circulating antibodies. Journal of General Virology 45:703–710
    [Google Scholar]
  13. Lehmann-Grube F. 1964; Lymphocytic choriomeningitis in the mouse. I. Growth in the brain. Archiv fur die gesamte Virusforschung 14:344–350
    [Google Scholar]
  14. Lehmann-Grube F. 1969; Dose-response relationships of lymphocytic choriomeningitis viruses in mice and L cell tube cultures. Journal of Hygiene 67:269–278
    [Google Scholar]
  15. Lehmann-Grube F. 1981; Infection of mice with lymphocytic choriomeningitis virus. In The Mouse in Biomedical Research Edited by Foster H. L., Small J. D., Fox J. G. New York: Academic Press; (in press)
    [Google Scholar]
  16. Lehmann-Grube F., Ambrassat J. 1977; A new method to detect lymphocytic choriomeningitis virus-specific antibody in human sera. Journal of General Virology 37:85–92
    [Google Scholar]
  17. Lehmann-Grube F., Lohler J. 1981; Immunopathologic alterations of lymphatic tissues of mice infected with lymphocytic choriomeningitis virus. II. Pathogenetic mechanism. Laboratory Investigation 44:205–213
    [Google Scholar]
  18. Lehmann-Grube F., Martinez Peralta L., Bruns M., Lohler J. 1981a; Persistent infection of mice with lymphocytic choriomeningitis virus. In Comprehensive Virology Edited by Fraenkel-Conrat H., Wagner R. R. New York: Plenum Press; (in press)
    [Google Scholar]
  19. Lehmann-Grube F., Varho M., Cihak J. 1981b; Reciprocal patterns of humoral and cell-mediated anti viral immune responses of mice infected with high and low doses of lymphocytic choriomeningitis virus. In The Replication of Negative Strand Viruses pp 85–92 Edited by Bishop D. H. L., Compans R. W. New York & Amsterdam: Elsevier/North-Holland;
    [Google Scholar]
  20. Mackaness G. B., Lagrange P. H., Miller T. E., Ishibashi T. 1974; Feedback inhibition of specifically sensitized lymphocytes. Journal of Experimental Medicine 139:543–559
    [Google Scholar]
  21. Popescu M., Lehmann-Grube F. 1976; Diversity of lymphocytic choriomeningitis virus: variation due to replication of the virus in the mouse. Journal of General Virology 30:113–122
    [Google Scholar]
  22. Popescu M., Löhler J., Lehmann-Grube F. 1979; Infectious lymphocytes in lymphocytic choriomeningitis virus carrier mice. Journal of General Virology 42:481–492
    [Google Scholar]
  23. Rivers T. M., Scott T. F. M. 1936; Meningitis in man caused by a filterable virus. II. Identification of the etiological agent. Journal of Experimental Medicine 63:415–432
    [Google Scholar]
  24. Suzuki S., Hotchin J. 1971; Initiation of persistent lymphocytic choriomeningitis infection in adult mice. Journal of Infectious Diseases 123:603–610
    [Google Scholar]
  25. Tijerina R., Lohler J., Chaturvedi U. C., Lehmann-Grube F. 1980; Infection of murine T lymphocytes with lymphocytic choriomeningitis virus: effect of age of mice on susceptibility. Zeitschrift fur Naturforschung 35c:1062–1065
    [Google Scholar]
  26. Zinkernagel R. M., Doherty P. C. 1979; MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, functions, and responsiveness. Advances in Immunology 27:51–177
    [Google Scholar]
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