@article{mbs:/content/journal/jgv/10.1099/0022-1317-58-1-37, author = "Chanas, A. C. and Gould, E. A. and Clegg, J. C. S. and Varma, M. G. R.", title = "Monoclonal Antibodies to Sindbis Virus Glycoprotein E1 can Neutralize, Enhance Infectivity, and Independently Inhibit Haemagglutination or Haemolysis", journal= "Journal of General Virology", year = "1982", volume = "58", number = "1", pages = "37-46", doi = "https://doi.org/10.1099/0022-1317-58-1-37", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-58-1-37", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "monoclonal", keywords = "enhancement", keywords = "haemolysis", keywords = "Sindbis", abstract = "SUMMARY Two monoclonal antibodies raised against Sindbis virus were shown to be specific for the envelope glycoprotein E1 by radioimmunoprecipitation (RIP). They had a number of contrasting biological properties. One of them was capable of neutralizing virus infectivity and inhibiting haemagglutination, while the other had no significant neutralizing or haemagglutination-inhibiting capability, but did inhibit virus-mediated haemolysis. Both monoclonal antibodies could enhance virus infectivity of Fc receptor-bearing macrophage-like cells when present at suitable dilutions.", }