1887

Abstract

SUMMARY

Antigenic relationships among the matrix proteins of influenza A viruses were analysed using a competitive radioimmunoassay technique. There were at least two antigenic determinants on the M protein of A/PR/8/34 virus. One antigenic determinant was shared by several influenza A viruses of human, avian, swine or equine origin, while the second determinant was not necessarily shared by all influenza viruses since it was not detected on the M protein of A/chicken/Germany/N/49 virus. In addition, the cross-reactive determinant(s) of the M protein of N virus was not equally represented in other influenza A virus subtypes.

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1981-12-01
2024-04-25
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References

  1. Both G. W., Air G. M. 1979; Nucleotide sequence coding for the N-terminal region of the matrix protein of influenza virus. European Journal of Biochemistry 96:363–372
    [Google Scholar]
  2. Brand C. M., Skehel J. J. 1972; Crystalline antigen from the influenza virus envelope. Nature New Biology 238:145–147
    [Google Scholar]
  3. Compans R. W., Klenk H. D., Caliguiri L. A., Choppin P. W. 1970; Influenza virus protein. I. Analysis of polypeptides of the virion and identification of spike glycoproteins. Virology 42:880–889
    [Google Scholar]
  4. Haslam E. A., Hampson A. W., Radiskvics I., White D. O. 1970; The polypeptides of influenza virus. III. Identification of the hemagglutinin, neuraminidase and nucleocapsid proteins. Virology 42:566–575
    [Google Scholar]
  5. Laemmli U. K. 1970; Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, London 227:680–685
    [Google Scholar]
  6. Lecomte J., Croteau G. 1981; Separation of M-protein from influenza virus by agarose gel electrophoresis. Journal of Virological Methods 2:211–221
    [Google Scholar]
  7. Lecomte J., Berthiaume L., Boudreault A. 1979; Influenza viruses in birds: rapid identification by counterimmunoelectrophoresis. Journal of Clinical Microbiology 9:128–133
    [Google Scholar]
  8. Montelaro R. C., Bolognesi D. P. 1979; A procedure for the preferential radioiodination of small amounts of protein in the presence of excess lipids. Analytical Biochemistry 99:92–96
    [Google Scholar]
  9. Oxford I. S., Schild G. C. 1975; Immunological studies with influenza virus matrix protein. In Negative Strand Viruses vol 2 pp. 611–620 Edited by Mahy B. W. J., Barry R. D. London: Academic Press;
    [Google Scholar]
  10. Oxford J. S., Schild G. C. 1976; Immunological and physiochemical studies of influenza matrix (M) polypeptides. Virology 74:394–402
    [Google Scholar]
  11. Schild G. C. 1972; Evidence for a new type-specific structural antigen of the influenza virus particle. Journal of General Virology 15:99–103
    [Google Scholar]
  12. Skehel J. J., Schild G. C. 1971; The polypeptide composition of influenza A viruses. Virology 44:396–408
    [Google Scholar]
  13. Winter G., Field S. 1980; Cloning of influenza CDNA into M13: the sequence of the RNA segment encoding the A/PR/8/34 matrix protein. Nucleic Acids-Research 8:1965–1971
    [Google Scholar]
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