1887

Abstract

SUMMARY

An ecotropic type C retrovirus (D1-MuLV) isolated from SJL/J mice was injected into neonatally thymectomized SJL/J mice. There was no acceleration of development of reticulum cell neoplasm (RCN) in these mice as compared with the control, uninoculated but similarly thymectomized group. The incidence of RCN at 10 and 11 months after injection was 14.6% and 12.5% respectively. Two female mice inoculated with D1-MuLV developed mammary adenocarcinoma. There was persistence of high titres of the ecotropic virus associated with RCN and mammary tumour of SJL/J mice. Xenotropic virus (X-MuLV) was detected in spleens of normal SJL/J mice at ages 6 and 12 months (60% and 80% respectively) but not at other ages. The X-MuLV isolated from SJL/J mouse embryo cell cultures treated with 5-iodo-2′-deoxyuridine (SJL-MEF-X-MuLV) and that isolated from a spontaneous RCN (SJL-RCN-X-MuLV) were compared with NZB-X-MuLV (NZB mouse origin) and AT124-X-MuLV (NIH Swiss mouse origin) in regard to their host range, ion and primer-template preference by reverse transcriptase, virus interference and neutralization characteristics. Cross-neutralization and gp70 competitive radio-immunoassays showed that D1-MuLV is more closely related to AKR-MuLV than to Rauscher-MuLV and appears to share some virus envelope antigens with SJL-X-MuLVs. The type-specific gene product (p12) from Balb:virus-2 and NZB-X-MuLV was used in competitive radioimmunoassay, and SJL-RCN-X-MuLV was found to be more closely related to Balb:virus-2 (MuLV-X) than to NZB-X-MuLV (MuLV-X).

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1981-11-01
2024-04-18
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References

  1. Aaronson S. A., Stephenson J. R. 1973; Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells. Proceedings of the National Academy of Sciences of the United States of America 70:2055–2058
    [Google Scholar]
  2. Callahan R., Lieber M. M., Todaro G. J. 1975; Nucleic acid homology of murine xenotropic type C viruses. Journal of Virology 15:1378–1384
    [Google Scholar]
  3. Chang K. S. S., Law L. W., Aoki T. 1974; Type C RNA virus isolated from SJL/J mice. Journal of the National Cancer Institute 52:777–784
    [Google Scholar]
  4. Chang K. S. S., Aoki T., Law L. W. 1975; Isolation of a B-tropic type-C virus from reticulum cell neoplasms induced in BALB/c mice by SJL/J type-C virus. Journal of the National Cancer Institute 54:83–87
    [Google Scholar]
  5. Cloyd M. W., Hartley J. W., Rowe W. P. 1980; Lymphomagenicity of recombinant milk cell focus-inducing murine leukemia viruses. Journal of Experimental Medicine 151:542–552
    [Google Scholar]
  6. Dawson P. J., Fieldsteel H. A. 1974; Reticulum cell sarcomas induced in mice by Rauscher virus. Journal of the National Cancer Institute 52:1805–1809
    [Google Scholar]
  7. Dion A. S., Vaidya A. B., Fout G. S. 1974; Cation preference for poly(rC)-oligo-(dG)-directed DNA synthesis by RNA tumor viruses and human milk particulates. Cancer Research 34:3509–3515
    [Google Scholar]
  8. Elder J. H., Gautsch J. W., Jensen F. C., Lerner R. A., Chused T. M., Morse H. C., Hartley J. W., Rowe W. P. 1980; Differential expression of two distinct xenotropic viruses in NZB mice. Clinical Immunobiology and Immunopathology 15:493–501
    [Google Scholar]
  9. Haas M., Meshorer A. 1979; Reticulum cell neoplasms induced in C57BL/6 mice by cultured virus grown in stromal hematopoietic cell lines. Journal of the National Cancer Institute 63:427–438
    [Google Scholar]
  10. Haran-Ghera N., Kotler M., Meshorer A. 1967; Studies on leukemia development in the SJL/J strain of mice. Journal of the National Cancer Institute 39:653–661
    [Google Scholar]
  11. Hartley J. W., Wolford N. K., Old L. J., Rowe W. P. 1977; A new class of murine leukemia viruses associated with the development of spontaneous lymphoma. Proceedings of the National Academy of Sciences of the United State of America 74:789–792
    [Google Scholar]
  12. Latarjet R., Duplan J. F. 1962; Experiments and discussion on leukemogenesis by cell-free extracts of radiation-induced leukemia in mice. International Journal of Radiation Biology 5:339–344
    [Google Scholar]
  13. Levy J. A. 1978; Xenotropic type C viruses. Current Topics in Mircobiology and Immunology 79:111–213
    [Google Scholar]
  14. Levy J. A., Kazan P., Vernier O., Kleiman H. 1975; Murine xenotropic C-type viruses. I. Distribution and further characterization of the virus in NZB mice. Journal of Virology 16:844–853
    [Google Scholar]
  15. Log T., Chang K. S. S., Sarma P. S. 1978; Production of antibodies against feline leukemia and sarcoma viruses and the feline oncovirus-associated cell membrane antigen in strain 2 guinea pigs. Virology 89:300–305
    [Google Scholar]
  16. Lostrom M. E., Stone M. R., Tam M., Burnette W. N., Pinter A., Nowinski R. C. 1979; Monoclonal antibodies against murine leukemia viruses: identification of six antigenic determinants on the p15(E) and gp70 envelope proteins. Virology 98:336–350
    [Google Scholar]
  17. McLntlre K. R., Law L. W. 1967; Abnormal serum immunoglobulins occurring with reticular neoplasms in an inbred strain of mouse. Journal of the National Cancer Institute 39:1197–1211
    [Google Scholar]
  18. Nelson-Rees W. A., Flandermeyer R. R. 1976; HeLa cultures defined. Science 191:96–98
    [Google Scholar]
  19. Peebles P. T. 1975; An in vitro focus-induction assay for xenotropic murine leukemia virus, feline leukemia virus C, and the feline-primate viruses RD-114/CCC/M7. Virology 67:288–291
    [Google Scholar]
  20. Rhim J. S., Cho H. Y., Huebner R. J. 1975; Nonproducer human cells induced by murine sarcoma virus. International Journal of Cancer 15:23–29
    [Google Scholar]
  21. Siegler R. 1968; Pathology of murine leukemias. In Experimental Leukemia pp 51–95 Edited by Rich M. A. Amsterdam: North-Holland;
    [Google Scholar]
  22. Stephenson J. R., Reynolds R. K., Tronick S. R., Aaronson S. A. 1975; Distribution of three classes of endogenous type-C RNA viruses among inbred strains of mice. Virology 67:404–414
    [Google Scholar]
  23. Strand M., August J. T. 1975; Structural proteins of mammalian RNA tumor viruses: relatedness of the interspecies antigenic determinants of the major internal protein. Journal of Virology 15:1332–1341
    [Google Scholar]
  24. Todaro G. J., Arnstein P., Parks W. P., Lennette E. H., Huebner R. J. 1973; A type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with anti-lymphocyte serum. Proceedings of the National Academy of Sciences of the United States of America 70859–862
    [Google Scholar]
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