1887

Abstract

Summary

Human adenovirus type 5 caused acute hepatocellular damage when injected intravenously into C57B1/6 mice. Early protein (P) and late virus protein (V) antigen staining by immunofluorescence was located principally, if not exclusively, in hepatocytes. Autoradiography following incorporation of tritiated thymidine into Ad5-infected liver cells indicated that DNA synthesis was initiated in hepatocytes. Flow cytometry showed that cells with a 4n DNA content prior to infection were highly susceptible to infection, with 75% being lost from the liver cell population by 5 days post-infection. This observation was correlated with the observed pathology during the course of the infection.

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/content/journal/jgv/10.1099/0022-1317-57-1-221
1981-11-01
2019-11-22
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-57-1-221
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