1887

Journal of General Virology header logo

Volume 57, Issue 1

Differentiation of Measles Virus Strains and a Strain of Canine Distemper Virus by Monoclonal Antibodies Free

Abstract

SUMMARY

Monoclonal antibodies raised against the Hallé strain of measles virus were tested for their strain specificity using other measles virus isolates (Edmonston, Leningrad, Lec and two fresh isolates JT and Fasquelle). Monoclonal antibodies to L, HA and NP polypeptides, with one exception, reacted with all the measles virus strains tested; antibody from hybrid line 25 failed to react with the NP polypeptide of JT virus by immunofluorescence or radioimmunoprecipitation. Three other monoclonal antibodies, two reacting with NP and one with HA, although giving a positive immunofluorescence reaction, did not immunoprecipitate labelled antigen from JT virus-infected cells. The immunological relationship of canine distemper and measles viruses was also investigated with monoclonal antibodies. Two of the three anti-NP and three of the four anti-HA monoclonal antibodies reacted with canine distemper virus in an immunofluorescence reaction but only one (anti-NP) reacted in a radioimmunoprecipitation test.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): canine distemper , measles , monoclonal and SSPE
© Journal of General Virology 1981
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-57-1-179
1981-11-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/57/1/JV0570010179.html?itemId=/content/journal/jgv/10.1099/0022-1317-57-1-179&mimeType=html&fmt=ahah

References

  1. Cook S. D., Dowling P. C., Russell W. C. 1979; Neutralizing antibodies to canine distemper and measles virus in multiple sclerosis. Journal of Neurological Science 41:61–70
     [Google Scholar]
  2. Flamand A., Wiktor T. J., Koprowski H. 1980a; Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. I. The nucleocapsid protein. Journal of General Virology 48:97–104
     [Google Scholar]
  3. Flamand A., Wiktor T. J., Koprowski H. 1980b; Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. II. The glycoprotein. Journal of General Virology 48:105–109
     [Google Scholar]
  4. Giraudon P., Wild T. F. 1981; Monoclonal antibodies against measles virus. Journal of General Virology 54:325–332
     [Google Scholar]
  5. Hall W., Lamb R. A., Choppin P. W. 1980; The polypeptides of canine distemper virus: synthesis in infected cells and relatedness to the polypeptides of other morbilliviruses. Virology 100:433–449
     [Google Scholar]
  6. Köhler G., Milstein C. 1975; Continuous cultures of fused cells secreting of predefined specificity. Nature, London 256:495–497
     [Google Scholar]
  7. Orvell C., Norrby E. 1974; Further studies on the immunologic relationships among measles, distemper, and rinderpest viruses. Journal of Immunology 113:1850–1858
     [Google Scholar]
  8. Pereira L., Klassen T., Baringer J. R. 1980; Type-common and type-specific monoclonal antibody to herpes simplex virus type 1. Infection and Immunity 29:724–732
     [Google Scholar]
  9. Trudgett A., Gould E. A., Armstrong M., Mingioli E. S., Macfarlin D. E. 1981; Antigenic differences in the hemagglutinin of measles and related viruses. Virology 109:180–182
     [Google Scholar]
  10. Wild T. F., Huppert J. 1980; Specificity of measles and canine distemper virus antibodies. Annates de I’Institut Pasteur 131E:73–84
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-57-1-179
Loading
Differentiation of Measles Virus Strains and a Strain of Canine Distemper Virus by Monoclonal Antibodies
J. Gen. Virol. 57, 179 (1981); https://doi.org/10.1099/0022-1317-57-1-179
/content/journal/jgv/10.1099/0022-1317-57-1-179
/content/journal/jgv/10.1099/0022-1317-57-1-179
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error