DNA Methylation—A Regulatory Signal in Eukaryotic Gene Expression

References

1. Adams R. L. P., Mckay E. L., Craig L. M., Burdon R. H. 1979; Mouse DNA methylase: methylation of native DNA. Biochimica et Biophysica Acta 561:345–357
   [Google Scholar]
2. Arber W. 1974; DNA modification and restriction. Progress in Nucleic Acid Research and Molecular Biology 14:1–37
   [Google Scholar]
3. Arber W., Linn S. 1969; DNA modification and restriction. Annual Review of Biochemistry 38:467–500
   [Google Scholar]
4. Auer B., Gunthert U., Wagner E. F., Schweiger M. 1979; Is the DNA of virus T7 methylated?. Journal of General Virology 44:609–613
   [Google Scholar]
5. Baker C. C., Ziff E. B. 1981; Promoters and heterogeneous 5′ termini of the messenger RNAs of adenovirus-2. Journal of Molecular Biology (in press)
   [Google Scholar]
6. Behe M., Felsenfeld G. 1981; Effects of methylation on a synthetic polynucleotide: the B-Z transition in poly(dG-m⁵dC)-poly(dG-⁵dC). Proceedings of the National Academy of Sciences of the United States of America 78:1619–1623
   [Google Scholar]
7. Behe M., Zimmerman S., Felsenfeld G. 1981; Changes in the helical repeat of poly(dG-m⁵dC)-poly(dG-m⁵dC) and poly(dG-dC)-poly(dG-dC) associated with the B-Z transition. Nature, London (in press)
   [Google Scholar]
8. Billen D. 1968; Methylation of the bacterial chromosome: an event at the ‘replication point’?. Journal of Molecular Biology 31:477–486
   [Google Scholar]
9. Bird A. P. 1978; Use of restriction enzymes to study eukaryotic DNA methylation: II. The symmetry of methylated sites supports semi-conservative copying of the methylation pattern. Journal of Molecular Biology 118:49–60
   [Google Scholar]
10. Bird A. P., Southern E. M. 1978; Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis. Journal of Molecular Biology 118:27–47
    [Google Scholar]
11. Bird A. P., Taggart M. H., Smith B. A. 1979; Methylated and unmethylated DNA compartments in the sea urchin genome. Cell 17:889–901
    [Google Scholar]
12. Bird A. P., Taggart M. H., Gehring C. A. 1981; Methylated and unmethylated ribosomal RNA genes in the mouse. Cell (in press)
    [Google Scholar]
13. Boyer H. W. 1971; DNA restriction and modification mechanisms in bacteria. Annual Review of Microbiology 25:153–176
    [Google Scholar]
14. Bromberg S., Pratt K., Hattman S. 1981; Sequence specificity of the DNA-adenine methylase in the protozoan, Tetrahymena thermophila. Journal of Bacteriology (in press)
    [Google Scholar]
15. Browne M. J., Turnbull J. F., Mckay E. L., Adams R. L. P., Burden R. H. 1977; The sequence specificity of a mammalian DNA methylase. Nucleic Acids Research 4:1039–1045
    [Google Scholar]
16. Burton W. G., Grabowy C. T., Sager R. 1979; Role of methylation in the modification and restriction of chloroplast DNA in Chlamydomonas. Proceedings of the National Academy of Sciences of the United States of America 76:1390–1394
    [Google Scholar]
17. Chow L. T., Broker T. R., Lewis J. B. 1979; Complex splicing patterns of RNAs from the early regions of adenovirus 2. Journal of Molecular Biology 134:265–303
    [Google Scholar]
18. Christman J. K., Price P., Pedrinan L., Acs G. 1977; Correlation between hypomethylation of DNA and expression of globin genes in Friend erythroleukemia cells. European Journal of Biochemistry 81:53–61
    [Google Scholar]
19. Christman J. K., Weich N., Schoenbrun B., Schneiderman N., Acs G. 1980; Hypomethylation of DNA during differentiation of Friend erythroleukemia cells. Journal of Cell Biology 86:366–370
    [Google Scholar]
20. Cohen J. C. 1980; Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA. Cell 19:653–662
    [Google Scholar]
21. Constantinides P. G., Jones P. A., Gevers W. 1977; Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment. Nature, London 267:364–366
    [Google Scholar]
22. Coulondre C., Miller J. H., Farabaugh P. J., Gilbert W. 1978; Molecular basis of base substitution hotspots in Escherichia coli. Nature, London 274:775–780
    [Google Scholar]
23. Cummings D. J., Tait A., Goddard J. M. 1974; Methylated bases in DNA from Paramecium aurelia. Biochimica et Biophysica Acta 374:1–11
    [Google Scholar]
24. Desrosiers R. C. 1981; Methylation of Herpesvirus saimiri DNA in tumor cells. International Workshop on Herpesviruses Bologna, Italy: (abstract)
    [Google Scholar]
25. Desrosiers R. C., Mulder C., Fleckenstein B. 1979; Methylation of Herpesvirus saimiri DNA in lymphoid tumor cell lines. Proceedings of the National Academy of Sciences of the United State of America 76:3839–3843
    [Google Scholar]
26. Deumling B. 1981; Sequence arrangement of a highly methylated satellite DNA of a plant, Scilla: a tandemly repeated inverted repeat. Proceedings of the National Academy of Sciences of the United States of America 78:338–342
    [Google Scholar]
27. Doerfler W. 1968; The fate of the DNA of adenovirus type 12 in baby hamster kidney cells. Proceedings of the National Academy of Sciences of the United States of America 60:636–643
    [Google Scholar]
28. Doerfler W. 1969; Nonproductive infection of baby hamster kidney cells (BHK21) with adenovirus type 12.. Virology 38:587–606
    [Google Scholar]
29. Doerfler W. 1970; Integration of the DNA of adenovirus type 12 into the DNA of baby hamster kidney cells. Journal of Virology 6:652–666
    [Google Scholar]
30. Doerfler W. 1975; Integration of viral DNA into the host genome. Current Topics in Microbiology and Immunology 71:1–78
    [Google Scholar]
31. Doerfler W. 1977; Animal virus-host genome interactions. In Comprehensive Virology vol 10 pp 279–399 Edited by Fraenkel-Conrat H., Wagner R. R. New York: Plenum Press;
    [Google Scholar]
32. Doerfler W. 1982; Uptake, fixation and expression of foreign DNA in mammalian cells: the organization of integrated adenovirus DNA sequences. Current Topics in Microbiology and Immunology (in press)
    [Google Scholar]
33. Doerfler W., Lundholm U. 1970; Absence of replication of the DNA of adenovirus type 12 in BHK21 cells. Virology 40:754–757
    [Google Scholar]
34. Doskocil J., Sorm F. 1962; Distribution of 5-methylcytosine in pyrimidine sequences of DNA. Biochimica et Biophysica Acta 55:953–959
    [Google Scholar]
35. Doskocil J., Sormova Z. 1965; The occurrence of 5-methylcytosine in bacterial deoxyribonucleic acid. Biochimica et Biophysica Acta 95:513–514
    [Google Scholar]
36. Drahovsky D., Boehm T. L. J. 1980; Enzymatic DNA methylation in higher eukaryotes. International Journal of Biochemistry 12:523–528
    [Google Scholar]
37. Drahovsky D., Boehm T. L. J., Kreis W. 1979; Distribution pattern and enzymic hypermethylation of inverted repetitive DNA sequences in P815 mastocytoma cells. Biochimica et Biophysica Acta 563:28–35
    [Google Scholar]
38. Drozhdenyuk A. P., Sulimova G. E., Vanyushin B. F. 1977; Content of 5-methylcytosine in different families of repeating sequences of some higher plant DNA. Biokhimiya 42:1439–1444
    [Google Scholar]
39. Dunn D. B., Smith J. D. 1958; The occurrence of 6-methylaminopurine in deoxyribonucleic acid. Biochemical Journal 68:627–636
    [Google Scholar]
40. Eden F. C., Musti A. M., Sobieski D. A. 1981; Clusters of repeated sequences of chicken DNA are extensively methylated but contain specific undermethylated regions. Journal of Molecular Biology 148:129–151
    [Google Scholar]
41. Ehrlich M., Wang R. Y. H. 1981; 5-methylcytosine in eukaryotic DNA. Science 212:1350–1357
    [Google Scholar]
42. Eick D., Stabel S., Doerfler W. 1980; Revertants of adenovirus type 12-transformed hamster cell line T637 as tools in the analysis of integration patterns. Journal of Virology 36:41–49
    [Google Scholar]
43. Esche H. 1981; Viral gene products in adenovirus type 2-transformed hamster cells. Journal of Virology (in press)
    [Google Scholar]
44. Esche H., Schilling R., Doerfler W. 1979; In vitro translation of adenovirus type 12-specific mRNA isolated from infected and transformed cells. Journal of Virology 30:21–31
    [Google Scholar]
45. Fanning E., Doerfler W. 1976; Intracellular forms of adenovirus DNA. V. Viral DNA sequences in hamster cells abortively infected and transformed with human adenovirus type 12. Journal of Virology 20:373–383
    [Google Scholar]
46. Fiers W., Contreras R., Haegeman G., Rogiers R., Van De Voorde A., Van Heuverswyn H., Van Herreweghe J., Volkaert G., Ysebaert M. 1978; Complete nucleotide sequence of SV40 DNA. Nature, London 273:113–120
    [Google Scholar]
47. Garel A., Zolan M., Axel R. 1977; Genes transcribed at diverse rates have similar conformation in chromatin. Proceedings of the National Academy of Sciences of the United States of America 74:4867–4871
    [Google Scholar]
48. Garovsky M. A., Hattman S., Pleger G. L. 1973; [⁶N]methyl adenine in the nuclear DNA of a eucaryote, Tetrahymena pyriformis. Journal of Cell Biology 56:697–701
    [Google Scholar]
49. Gautier F., Bünemann H., Grotjahn L. 1977; Analysis of calf-thymus satellite DNA: evidence for specific methylation of cytosine in C-G sequences. European Journal of Biochemistry 80:175–183
    [Google Scholar]
50. Glickman B., Van Den Elsen P., Radman M. 1978; Induced mutagenesis in danr mutants of Escherichia coli: a role for 6-methyladenine residues in mutation avoidance. Molecular and General Genetics 163:307–312
    [Google Scholar]
51. Grippo P., Iacarrino M., Parisi E., Scarano E. 1968; Methylation of DNA in developing sea urchin embryos. Journal of Molecular Biology 36:195–208
    [Google Scholar]
52. Grippo P., Parisi E., Carestia C., Scarano E. 1970; A novel origin of some DNA thymine and its nonrandom distribution. Biochemistry 9:2605–2609
    [Google Scholar]
53. Groneberg J., Doerfler W. 1979; Revertants of adenovirus type 12-transformed hamster cells have lost part of the viral genomes. International Journal of Cancer 24:67–74
    [Google Scholar]
54. Groneberg J., Sutter D., Soboll H., Doerfler W. 1978; Morphological revertants of adenovirus type 12-transformed hamster cells. Journal of General Virology 40:635–645
    [Google Scholar]
55. Groudine M., Eisenmann R., Weintraub H. 1981; Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation. Nature, London 292:311–317
    [Google Scholar]
56. Gruenbaum Y., Naveh-Many T., Cedar H., Razin A. 1981; Sequence specificity of methylation in higher plant DNA. Nature, London 292:860–862
    [Google Scholar]
57. Guntaka R. V., Rao P. Y., Mitsialis S. A., Katz R. 1980; Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells. Journal of Virology 34:569–572
    [Google Scholar]
58. Gunthert U., Schweiger M., Stupp M., Doerfler W. 1976; DNA methylation in adenovirus, adenovirus transformed cells, and host cells. Proceedings of the National Academy of Sciences of the United States of America 73:3923–3927
    [Google Scholar]
59. Harbers K., Schnieke A., Stuhlmann H., Jahner D., Jaenisch R. 1981; DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning. Proceedings of the National Academy of Sciences of the United States of America 78: (in press)
    [Google Scholar]
60. Hattman S. 1981; DNA methylation. In The Enzymes New York & London: (in press)
    [Google Scholar]
61. Hattman S., Schlagman S., Cousens L. 1973; Isolation of a mutant of Escherichia coli defective in cytosine-specific DNA methylase activity and in partial protection of bacteriophage X against restriction by cells containing the N-3 drug resistance factor. Journal of Bacteriology 115:1103–1107
    [Google Scholar]
62. Hattman S., Kenny C., Berger L., Pratt K. 1978; Comparative study of DNA methylation in three unicellular eukaryotes. Journal of Bacteriology 135:1156–1157
    [Google Scholar]
63. Holliday R., Pugh J. E. 1975; DNA modification mechanisms and gene activity during development. Science 187:226–232
    [Google Scholar]
64. Hotchkiss R. D. 1948; The quantitative separation of purines, pyrimidines and nucleosides by paper chromatography. Journal of Biological Chemistry 175:315–332
    [Google Scholar]
65. Johansson K., Persson H., Lewis A. M., Pettersson U., Tibbetts C., Philipson L. 1978; Viral DNA sequences and gene products in hamster cells transformed by adenovirus type 2. Journal of Virology 27:628–639
    [Google Scholar]
66. Johnson T. B., Coghill R. D. 1925; Researches on pyrimidines. CIII. The discovery of 5-methyl-cytosine in tuberculinic acid, the nucleic acid of the tubercle bacillus. Journal of the American Chemical Society 47:2838–2844
    [Google Scholar]
67. Jones P. A., Taylor S. M. 1980; Cellular differentiation, cytidine analogs and DNA methylation. Cell 20:85–93
    [Google Scholar]
68. Jones P. A., Taylor S. M. 1981; Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells. Nucleic Acids Research 9:2933–2947
    [Google Scholar]
69. Josse J., Kaiser A. D., Kornberg A. 1961; Frequencies of nearest neighbor base sequences in DNA. Journal of Biological Chemistry 236:864–875
    [Google Scholar]
70. Kaput J., Sneider J. W. 1979; Methylation of somatic vs germ cell DNAs analyzed by restriction endonuclease digestion. Nucleic Acids Research 7:2303–2322
    [Google Scholar]
71. Karran P., Lindahl T., Griffin B. 1979; Adaptive response to alkylating agents involves alteration in situ of 0⁶ methyl-guanine residues in DNA. Nature, London 280:76–77
    [Google Scholar]
72. KaschkaDierich Ch., Fleckenstein B., Desrosiers R. C. 1981; Methylation of viral DNA in herpesvirus-transformed lymphoid primate tumor cells and cell lines. Spring Meeting of the Institute of Genetics Cologne (abstract)
    [Google Scholar]
73. Kaye A. M., Winocour E. 1967; On the 5-methyl-cytosine found in the DNA extracted from polyoma virus. Journal of Molecular Biology 24:475–478
    [Google Scholar]
74. Kintner S., Sugden B. 1981; Conservation and progressive methylation of Epstein-Barr viral DNA sequences in transformed cells. Journal of Virology 38:305–316
    [Google Scholar]
75. Kuhlmann I., Doerfler W. 1981; Shifts in the extent and patterns of DNA methylation upon explantation and subcultivation of adenovirus type 12-induced hamster tumor cells. Virology (in press)
    [Google Scholar]
76. Kuo M. T., Mandel J. L., Chambon P. 1979; DNA methylation: correlation with DNase I sensitivity of chicken ovalbumin and conalbumin chromatin. Nucleic Acids Research 7:2105–2113
    [Google Scholar]
77. Lafer E. M., Moller A., Nordheim A., Stollar B. D., Rich A. 1981; Antibodies specific for left-handed Z DNA. Proceedings of the National Academy of Sciences of the United States of America 78:3546–3550
    [Google Scholar]
78. Lapeyre J. N., Becker F. F. 1979; 5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result. Biochemical and Biophysical Research Communications 87:698–705
    [Google Scholar]
79. Lark C. 1968; Studies on the in vivo methylation of DNA in Escherichia coli 15T⁻. Journal of Molecular Biology 31:389–399
    [Google Scholar]
80. Lin S., Riggs A. D. 1972; Lac operator analogues: bromodeoxyuridine substitution in the lac operator affects the rate of dissociation of the lac repressor. Proceedings of the National Academy of Sciences of the United States of America 69:2574–2576
    [Google Scholar]
81. Lin S., Lin D., Riggs A. D. 1976; Histones bind more tightly to bromodeoxyuridine-substituted DNA than to normal DNA. Nucleic Acids Research 3:2183–2191
    [Google Scholar]
82. Low M., Hay J., Keir H. M. 1969; DNA of herpes simplex virus is not a substrate for methylation in vitro. Journal of Molecular Biology 46:205–207
    [Google Scholar]
83. Lubit B. W., Pham T. D., Miller O. J., Erlanger B. F. 1976; Localization of 5-methylcytosine in human metaphase chromosomes by immunoelectron microscopy. Cell 9:503–509
    [Google Scholar]
84. Lyon M. F. 1961; Gene action in the X chromosome of the mouse (Mus musculus L). Nature, London 190:372–373
    [Google Scholar]
85. Mcghee J. D., Ginder G. D. 1979; Specific DNA methylation sites in the vicinity of the chicken ß-giobin gene. Nature, London 280:419–420
    [Google Scholar]
86. Mandel J. L., Chambon P. 1979; DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes. Nucleic Acids Research 7:2081–2103
    [Google Scholar]
87. Mann M. B., Smith H. O. 1977; Specificity of Hpa II and Hae III methylases. Nucleic Acids Research 4:4211–4221
    [Google Scholar]
88. Marinus M. G., Morris N. R. 1973; Isolation of DNA methylase mutants of Escherichia coli K-12. Journal of Bacteriology 114:1143–1150
    [Google Scholar]
89. Marinus M. G., Morris N. R. 1975; Pleiotropic effects of a DNA adenine methylation mutation (dam-3) in Escherichia coliK. 12. Mutation Research 28:15–26
    [Google Scholar]
90. Maxam A. M., Gilbert W. 1977; A new method for sequencing DNA. Proceedings of the National Academy of Sciences of the United States of America 74:560–564
    [Google Scholar]
91. Meselson M., Yuan R., Heywood J. 1972; Restriction and modification of DNA. Annual Review of Biochemistry 41:447–466
    [Google Scholar]
92. Miller O. J., Schnedl W., Allen J., Erlanger B. F. 1974; 5-methylcytosine localised in mammalian constitutive heterochromatin. Nature, London 251:636–637
    [Google Scholar]
93. Modrich P. 1980; Structures and mechanisms of DNA restriction and modification enzymes. Quarterly Reviews of Biophysics 12:315–369
    [Google Scholar]
94. Mohandas T., Sparkes R. S., Shapiro L. J. 1981a; Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation. Science 211:393–396
    [Google Scholar]
95. Mohandas T., Sparkes R. S., Hellkuhl B., Grzechnik K. H., Shapiro L. J. 1981b Proceedings of the National Academy of Sciences of the United States of America 78: (in press)
    [Google Scholar]
96. Naveh-Many T., Cedar H. 1981; Active gene sequences are undermethylated. Proceedings of the National Academy of Sciences of the United States of America 78:4246–4250
    [Google Scholar]
97. Ohmori H., Tomizawa J., Maxam A. M. 1978; Detection of 5-methylcytosine in DNA sequences. Nucleic Acids Research 5:1479–1485
    [Google Scholar]
98. Olsson M., Lindahl T. 1980; Repair of alkylated DNA in Escherichia coli. Journal of Biological Chemistry 255:10569–10571
    [Google Scholar]
99. Ortin J., Scheidtmann K. H., Greenberg R., Westphal M., Doerfler W. 1976; Transcription of the genome of adenovirus type 12. III. Maps of stable RNA from productively infected human cells and abortively infected and transformed hamster cells. Journal of Virology 20:355–372
    [Google Scholar]
100. Pakhomova M. W., Zaitseva G. N., Belozerskii A. N. 1968; Differences in 5-methylcytosine and 6-methyl-adenine contents in the composition of the DNA of some algae (in Russian). Doklady Akademii Nauk SSSR 182:712–714
     [Google Scholar]
101. Palmiter R. D., Mulvihill E. R., Mcknight G. S., Senear A. W. 1977; Regulation of gene expression in the chicken oviduct by steroid hormones. Cold Spring Harbor Symposia on Quantitative Biology 42:639–647
     [Google Scholar]
102. Perucho M., Hanahan D., Wigler M. 1980; Genetic and physical linkage of exogenous sequences in transformed cells. Cell 22:309–317
     [Google Scholar]
103. Pollack Y., Stein R., Razin A., Cedar H. 1980; Methylation of foreign DNA sequences in eukaryotic cells. Proceedings of the National Academy of Sciences of the United States of America 77:6463–6467
     [Google Scholar]
104. Quint A., Cedar H. 1981; In vitro methylation of DNA with Hpall methylase. Nucleic Acids Research 9:633–646
     [Google Scholar]
105. Radman M., Wagner R., Glickman B., Meselson M. 1980; DNA methylation, mismatch correction and genetic stability. In Progress in Environmental Mutagenesis pp 121–130 Edited by Alacevic M. Amsterdam: Elsevier/North-Holland;
     [Google Scholar]
106. Randerath K., Randerath E. 1968; Thin-layer separation methods for nucleic acid derivatives. Methods in Enzymology 12:323–347
     [Google Scholar]
107. Razin A. 1978; Methylated bases in the single-stranded DNA phages. In The Single-stranded DNA Phages pp 165–175 Edited by Denhardt D. T., Dressier D., Ray D. S. New York: Cold Spring Harbor Laboratory, Cold Spring Harbor;
     [Google Scholar]
108. Razin A., Cedar H. 1977; Distribution of 5-methylcytosine in chromatin. Proceedings of the National Academy of Sciences of the United States of America 74:2725–2728
     [Google Scholar]
109. Razin A., Riggs A. D. 1980; DNA methylation and gene function. Science 210:604–610
     [Google Scholar]
110. Razin A., Sedat J. W. 1977; Analysis of 5-methylcytosine in TUN A. Analytical Biochemistry 77:370–377
     [Google Scholar]
111. Reddy V. B., Thimmapaya B., Dhar R., Subramanian K. N., Zain B. S., Pan J., Gosh P. K., Celma M. L., Weissman S. M. 1978; The genome of simian virus 40. Science 200:494–502
     [Google Scholar]
112. Riggs A. D. 1975; X inactivation, differentiation and DNA methylation. Cytogenetics and Cell Genetics 14:9–25
     [Google Scholar]
113. Roberts R. J. 1980; Restriction and modification enzymes and their recognition sequences. Nucleic Acids Research 8:r63–r80
     [Google Scholar]
114. Romanov G. A., Vanyushin B. F. 1981; Methylation of reiterated sequences in mammalian DNAs. Effects of the tissue type, age, malignancy and hormonal induction. Biochimica et Biophysica Acta 653:204–218
     [Google Scholar]
115. Roy P. H., Weissbach A. 1975; DNA methylase from HeLa cell nuclei. Nucleic Acids Research 2:1669–1684
     [Google Scholar]
116. Royer H. D., Sager R. 1979; Methylation of chloroplast DNA in the life cycle of Chlamydomonas. Proceedings of the National Academy of Sciences of the United States of America 76:5794–5798
     [Google Scholar]
117. Sager R., Kitchin R. 1975; Selective silencing of eukaryotic DNA. Science 189:426–433
     [Google Scholar]
118. Sager R., Lane D. 1972; Molecular basis of maternal inheritance. Proceedings of the National Academy of Sciences of the United States of America 69:2410–2413
     [Google Scholar]
119. Sager R., Grabowy C., Sano H. 1981; The mat-1 gene in Chlamydomonas regulates DNA methylation during gametogenesis. Cell 24:41–47
     [Google Scholar]
120. Salomon R., Kaye A. M. 1970; Methylation of mouse DNA in vivo: di- and tripyrimidine sequences containing 5-methylcytosine. Biochimica et Biophysica Acta 204:340–351
     [Google Scholar]
121. Sano H., Sager R. 1980; DNA methyltransferase from the eukaryote Chlamydomonas reinhardi. >European Journal of Biochemistry 105:471–480
     [Google Scholar]
122. Sano H., Royer H. D., Sager R. 1980; Identification of 5-methylcytosine in DNA fragments immobilized on nitrocellulose paper. Proceedings of the National Academy of Sciences of the United States of America 77:3581–3585
     [Google Scholar]
123. Sano H., Grabowy C., Sager R. 1981; Differential activity of DNA methyltransferase in the life cycle of Chlamydomonas reinhardi. Proceedings of the National Academy of Sciences of the United States of America 78:3118–3122
     [Google Scholar]
124. Scarano E., Iaccarino M., Grippo P., Parisi E. 1967; The heterogeneity of thymine methylgroup origin in DNA pyrimidine isostichs of developing sea urchin embryos. Proceedings of the National Academy of Sciences of the United States of America 57:1394–1400
     [Google Scholar]
125. Schirm S., Doerfler W. 1981; The expression of viral DNA in adenovirus type 12-transformed cells, in tumor cells and in revertants. Journal of Virology 39:694–702
     [Google Scholar]
126. Shapiro H. S., Chargaff E. 1960; Studies on the nucleotide arrangement in DNA. IV. Patterns of nucleotide sequence in the DNA of rye germ and its fractions. Biochimica et Biophysica Acta 39:68–82
     [Google Scholar]
127. Sharma S., Biswal N. 1977; Studies on the in vivo methylation of replicating herpes simplex type 1 DNA. Virology 82:265–274
     [Google Scholar]
128. Simon D., Grunert F., Von Acken U., Doring H. P., Kroger H. 1978; DNA-methylase from regenerating rat liver: purification and characterization. Nucleic Acids Research 5:2153–2167
     [Google Scholar]
129. Singer J., Stellwagen R. H., Roberts-Ems J., Riggs A. D. 1977; 5-methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine. Journal of Biological Chemistry 252:5509–5513
     [Google Scholar]
130. Singer J., Roberts Ems J., Luthardt F. W., Riggs A. D. 1979; Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit. Nucleic Acids Research 7:2369–2385
     [Google Scholar]
131. Sinsheimer R. 1955; The action of pancreatic deoxyribonuclease. II. Isomeric dinucleotides. Journal of Biological Chemisty 215:579–583
     [Google Scholar]
132. Sneider T. W. 1971; Methylation of mammalian DNA. II. The distribution of 5-methylcytosine in pyrimidine deoxyribonucleotide clusters in Novikoff hepatoma cell DNA. Journal of Biological Chemistry 246:4774–4783
     [Google Scholar]
133. Sneider T. W. 1972; Methylation of mammalian DNA. III. Terminal versus internal location of 5-methylcytosine in oligodeoxyribonucleotides from Novikoff hepatoma cell DNA. Journal of Biological Chemistry 247:2872–2875
     [Google Scholar]
134. Sneider T. W. 1980; The 5′ cytosine in CCGG is methylated in two eukaryotic DNAs and Msp I is sensitive to methylation at this site. Nucleic Acids Research 8:3829–3840
     [Google Scholar]
135. Sneider T. W., Teague W. M., Rogachevsky L. M. 1975; S-adenosylmethionine dependent DNA-cytosine 5-methyl-transferase from a Novikoff hepatoma cell line. Nucleic Acids Research 2:1685–1700
     [Google Scholar]
136. Sobieski D. A., Eden F. C. 1981; Clustering and methylation of repeated DNA persists as avian species evolve. Journal of Molecular Biology (in press)
     [Google Scholar]
137. Soeda E., Arrand J. R., Smolar N., Griffin B. E. 1979; Sequence from early region of polyoma virus DNA containing viral replication origin and encoding small, middle and (part of) large T antigens. Cell 17:357–370
     [Google Scholar]
138. Southern E. M. 1975; Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology 98:503–517
     [Google Scholar]
139. Stabel S., Doerfler W., Friis R. R. 1980; Integration sites of adenovirus type 12 DNA in transformed hamster cells and hamster tumor cells. Journal of Virology 36:22–40
     [Google Scholar]
140. Stalder J., Groudine M., Dodgson J. B., Engel J. D., Weintraub H. 1980; Hb switching in chickens. Cell 19:973–980
     [Google Scholar]
141. Stein R., Naveh T., Pollack Y., Razin A., Cedar H. 1981; Methylation of eukaryotic DNA. Spring Meeting of the Institute of Genetics Cologne (abstract)
     [Google Scholar]
142. Streeck R. E. 1980; Single-strand and double-strand cleavage at half-modified and fully modified recognition sites for the restriction nucleases Sau 3A and Taq I. Gene 12:267–275
     [Google Scholar]
143. Stuhlmann H., Jahner D., Jaenisch R. 1981; Infectivity and methylation of retroviral genomes is correlated with expression in the animal. Cell (in press)
     [Google Scholar]
144. Subak-Sharpe H., Burk R. R., Crawford L. V., Morrison J. M., Hay J., Keir H. M. 1966; An approach to evolutionary relationships of mammalian DNA viruses through analysis of the pattern of nearest neighbour base sequences. Cold Spring Harbor Symposia on Quantitative Biology 31:737–748
     [Google Scholar]
145. Sugisaki H., Sugimoto K., Takanami M., Shiroki K., Saito I., Shimojo H., Sawada Y., Uemizu Y., Uesugi S., Fujinaga K. 1980; Structure and gene organization in the transforming Hind III-G fragment of Adl2. Cell 20:777–786
     [Google Scholar]
146. Sutter D., Doerfler W. 1979; Methylation of integrated viral DNA sequences in hamster cells transformed by adenovirus 12. Cold Spring Harbor Symposia on Quantitative Biology 44:565–568
     [Google Scholar]
147. Sutter D., Doerfler W. 1980; Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression. Proceedings of the National Academy of Sciences of the United States of America 77:253–256
     [Google Scholar]
148. Sutter D., Westphal M., Doerfler W. 1978; Patterns of integration of viral DNA sequences in the genomes of adenovirus type 12-transformed hamster cells. Cell 14:569–585
     [Google Scholar]
149. Tantravahi U., Guntaka R. V., Erlanger B. F., Miller O. J. 1981; Amplified ribosomal RNA genes in a rat hepatoma cell line are enriched in 5-methylcytosine. Proceedings of the National Academy of Sciences of the United States of America 78:489–493
     [Google Scholar]
150. Taylor J. H. 1979; Enzymatic methylation of DNA: pattern and possible regulatory rules. Chromosome Structure. In Molecular Genetics part 3 pp 89–115 Edited by Taylor J. H. New York: Academic Press;
     [Google Scholar]
151. Taylor S. M., Jones P. A. 1979; Multiple new phenotypes induced in 10Tj and 3T3 cells treated with azacytidine. Cell 17:771–779
     [Google Scholar]
152. Tjia S., Carstens E. B., Doerfler W. 1979; Infection of Spodoptera frugiperda cells with Autographa californica nuclear polyhedrosis virus. II. The viral DNA and the kinetics of its replication. Virology 99:399–409
     [Google Scholar]
153. Turnbull J. F., Adams R. L. P. 1976; DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity. Nucleic Acids Research 3:677–695
     [Google Scholar]
154. Van Der Ploeg L. H. T., Flavell R. A. 1980; DNA methylation in the human γδß-globin locus in erythroid and nonerythroid tissues. Cell 19:947–958
     [Google Scholar]
155. Van Der Ploeg L. H. T., Groffen J., Flavell R. A. 1980; A novel type of secondary modification of two CCGG residues in human γδß-globin gene locus. Nucleic Acids Research 8:4563–4574
     [Google Scholar]
156. Vanyushin B. F., Belozersky A. N., Kokurina N. A., Kadirova D. X. 1968; 5-methylcytosine and methylaminopurine in bacterial DNA. Nature, London 218:1066–1067
     [Google Scholar]
157. Vanyushin B. F., Tkacheva S. G., Belozersky A. N. 1970; Rare bases in animal DNA. Nature, London 225:948–949
     [Google Scholar]
158. Vanyushin B. F., Mazin A. L., Vasilyev V. K., Belozersky A. N. 1973; The content of 5-methylcytosine in animal DNA: the species and tissue specificity. Biochimica et Biophysica Acta 299:397–403
     [Google Scholar]
159. Vardimon L., Neumann R., Kuhlman I., Sutter D., Doerfler W. 1980; DNA methylation and viral gene expression in adenovirus-transformed and -infected cells. Nucleic Acids Research 8:2461–2473
     [Google Scholar]
160. Vardimon L., Kuhlmann J., Cedar H., Doerfler W. 1981a; Methylation of adenovirus genes in transformed cells and in vitro: influence on the regulation of gene expression. European Journal of Cell Biology 25:13–15
     [Google Scholar]
161. Vardimon L., Kressmann A., Cedar H., Maechler M., Doerfler W. 1981b; The expression of a cloned adenovirus gene is inhibited by in vitro methylation. Proceedings of the National Academy of Sciences of the United States of America 78: (in press)
     [Google Scholar]
162. Varmus H. E., Quintrell N., Medeiros E., Bishop J. M., Nowinski R. C., Sarkar N. H. 1973; Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains. Journal of Molecular Biology 79:663–679
     [Google Scholar]
163. Von acken U., Simon D., Grunert F., Doring H. P., Kroger H. 1979; Methylation of viral DNA in vivo and in vitro. Virology 99:152–157
     [Google Scholar]
164. Vovis G. F., Horiuchi K., Zinder N. D. 1974; Kinetics of methylation of DNA by a restriction endonuclease from Escherichia coli B. Proceedings of the National Academy of Sciences of the United States of America 71:3810–3813
     [Google Scholar]
165. Waalwuk C., Flavell R. A. 1978a; Msp I, an isoschizomer of Hpa II which cleaves both unmethylated and methylated Hpa II sites. Nucleic Acids Research 5:3231–3236
     [Google Scholar]
166. Waalwuk C., Flavell R. A. 1978b; DNA methylation at a CCGG sequence in the large intron of the rabbit ß-globin gene: tissue-specific variations. Nucleic Acids Research 5:4631–4641
     [Google Scholar]
167. Wagner R. Jr, Meselson M. 1976; Repair tracts in mismatched DNA heteroduplexes. Proceedings of the National Academy of Sciences of the United States of America 73:4135–4139
     [Google Scholar]
168. Wagner E. F., Auer B., Schweiger M. 1979; Development of Escherichia coli virus T1: escape from host restriction. Journal of Virology 29:1229–1231
     [Google Scholar]
169. Wahl G. M., Stern M., Stark G. R. 1979; Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proceedings of the National Academy of Sciences of the United States of America 76:3683–3687
     [Google Scholar]
170. Weintraub H., Groudine M. 1976; Chromosomal subunits in active genes have an altered conformation. Science 193:848–856
     [Google Scholar]
171. Wigler M. H. 1981; The inheritance of methylation patterns in vertebrates. Cell 24:285–286
     [Google Scholar]
172. Wigler M., Pellicer A., Silverstein S., Axel R., Urlaub G., Chasin L. 1979a; DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 76:1373–1376
     [Google Scholar]
173. Wigler M., Sweet R., Sim G. K., Wold B., Pellicer A., Lacy E., Maniatis T., Silverstein S., Axel R. 1979b; Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell 16:777–785
     [Google Scholar]
174. Wigler M., Levy D., Perucho M. 1981; The somatic replication of DNA methylation. Cell 24:33–40
     [Google Scholar]
175. Willis D. B., Granoff A. 1980a; Frog virus 3 DNA is heavily methylated at CpG sequences. Virology 107:250–257
     [Google Scholar]
176. Willis D. B., Granoff A. 1980b; Frog virus 3 DNA is heavily methylated at CpG sequences. The Third Poxvirus-Iridovirus Workshop (abstract)
     [Google Scholar]
177. Wyatt G. R. 1951; Recognition and estimation of 5-methylcytosine in nucleic acids. Biochemical Journal 48:581–584
     [Google Scholar]
178. Yagi M., Koshland M. E. 1981; Expression of the J chain gene during B cell differentiation is inversely correlated with DNA methylation. Proceedings of the National Academy of Sciences of the United States of America 78: (in press)
     [Google Scholar]
179. Youssoufian H., Mulder C., Hammer S. M., Hirsch M. S. 1981; Viral DNA is methylated in a model system of herpes simplex virus latency. Spring Meeting of the Institute of Genetics Cologne (abstract)
     [Google Scholar]
180. Yuan R., Meselson M. 1970; A specific complex between a restriction endonuclease and its DNA substrate. Proceedings of the National Academy of Sciences of the United States of America 65357–362
     [Google Scholar]