1887

Abstract

SUMMARY

The genome and polypeptides of influenza A virus H3N2 strains isolated during the epidemic of 1979–1980 in the U.S.S.R. and G.D.R. have been analysed. Five varieties of H3N2 strains differing in a number of genes have been found. The isolates of the first group were similar to the A/Texas/1/77 strain in all the genes; the isolates of the second group were similar to the A/Bangkok/1/79 strain in all the genes; the strain representative of the third variety, contained all the genes except gene 4 close to those of the A/Bangkok/1/79 strain; the isolates of the fourth group contained genes 7 and 8 similar to those of the A/Bangkok/1/79 strain while the other genes corresponded to those of no strains under comparison; the viruses of the fifth group contained gene 3 similar to that of A/Moscow/406/76 strain, gene 7 was similar to that of A/Texas/1/77 strain and the other genes differed from all other strains compared. The data obtained indicate that during an influenza epidemic occurring in a certain region several influenza virus varieties of the same serotype can circulate simultaneously, differing not only in the antigenic specificity of the haemagglutinin, but also in other genes.

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1981-10-01
2022-09-25
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References

  1. Bean W. J., Cox N. J., Kendal A. P. 1980; Recombination of human influenza A viruses in nature. Nature, London 284:638–640
    [Google Scholar]
  2. Beare A. S., Kendal A. P., Cox N. J., Scholtissek C. 1980; Human trials with wild-type H1N1 and recombinant H3N2-H1N1 influenza A viruses at 1947–1978. Infection and Immunity 28:753–761
    [Google Scholar]
  3. Bonner W. M., Laskey R. A. 1970; A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. European Journal of Biochemistry 46:83–88
    [Google Scholar]
  4. Bulletin Of The World Health Organization 1974; 48:212
  5. Ghendon Y., Klimov A. I., Blagoveshenskaya O. V., Genkina D. B. 1979; Investigation of recombinants of human influenza and fowl plague viruses. Journal of General Virology 43:183–191
    [Google Scholar]
  6. Hay A. J., Bellamy A. R., Abraham G., Skehel J. J., Brand C. M., Webster R. G. 1977a; Procedures for characterization of the genetic material of candidate vaccine strains. Developments in Biological Standardization 39:15–24
    [Google Scholar]
  7. Hay A. J., Lomniczi B., Bellamy A. R., Skehel J. J. 1977b; Transcription of influenza virus genome. Virology 83:337–355
    [Google Scholar]
  8. Ito Y., Joklik W. K. 1972; Temperature-sensitive mutants of reovirus. I. Patterns of gene expression by mutants of groups C, D and E. Virology 50:189–201
    [Google Scholar]
  9. Kendal A. P., Schieble I., Cooney M. K., Chin I., Foy H. M., Noble G. R. 1978; Co-circulation of tWO influenza A (H3N2) antigenic variants detected by virus surveillance in individual communities. American Journal of Epidemiology 108:308–311
    [Google Scholar]
  10. Kendal A. P., Joseph I. M., Kobayashi G., Nelson D., Reyes C. R., Ross M. R., Sarandria J. L., White R., Woodall D. F., Noble G. R., Dowdle W. R. 1979; Laboratory-based surveillance of influenza virus in the United States during the winter of 1977–1978. I. Periods of prevalence of H1N1 and H3N2 influenza A strains, their relative rates of isolation in different age groups, and detection of antigenic variants. American Journal of Epidemiology 110:449–161
    [Google Scholar]
  11. Laemmli U. K. 1970; Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, London 227:680–685
    [Google Scholar]
  12. Rott R., Orlich M., Scholtissek C. 1979; Correlation of pathogenicity and gene constellation of influenza A virus. VI. Non-pathogenic recombinants derived from highly pathogenic parent strains. Journal of General Virology 44:471–477
    [Google Scholar]
  13. Russell W. C., Skehel J. J. 1972; The polypeptides of adenovirus infected cells. Journal of General Virology 15:45–57
    [Google Scholar]
  14. Scholtissek C., Rott R., Orlich M., Harms E., Rohde W. 1977; Correlation of pathogenicity and gene constellation of an influenza A virus (fowl plague). II. Exchange of a single gene. Virology 81:74–80
    [Google Scholar]
  15. Scholtissek C., Vallbracht A., Flehmig B., Rott R. 1979; Correlation of pathogenicity and gene constellation of influenza A viruses. II. Highly neurovirulent recombinants derived from non-neurovirulent or weakly neurovirulent parent virus strain. Virology 95:492–500
    [Google Scholar]
  16. Young J. F., Desselberger U., Palese P. 1979; Evolution of human influenza A viruses in nature: sequential mutations in the genomes of new H1N1 isolates. Cell 18:73–83
    [Google Scholar]
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