@article{mbs:/content/journal/jgv/10.1099/0022-1317-56-1-195, author = "Tsang, Linda W-L. and Chang, N. and Marusyk, R. G.", title = "An Interference Phenomenon Associated with a Measles Virus SSPE Isolate (Halle)", journal= "Journal of General Virology", year = "1981", volume = "56", number = "1", pages = "195-198", doi = "https://doi.org/10.1099/0022-1317-56-1-195", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-56-1-195", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "measles virus", keywords = "plaques", keywords = "interference", keywords = "SSPE isolate", abstract = "SUMMARY A measles virus (Halle SSPE isolate) induced ring plaque phenomenon (concentric rings of living and dead cells) has been shown to be associated with the temperature-dependent production of interfering particles. The interfering particles have been purified by potassium tartrate linear gradient centrifugation and have buoyant densities of 1.15 g/ml (M particle) and 1.06 g/ml (L particle) respectively. Both interfering particle populations have been shown to decrease the yield of wild-type measles virus from infected cells by 50% when co-infection experiments were performed. Neither the M or L particle population interfered with the growth of VSV in the same host-cell system.", }