1887

Abstract

SUMMARY

We have studied the relationship between Friend spleen focus-forming virus (SFFV) and its helper lymphoid leukaemia virus (LLV) by comparing RNase T1 fingerprints of genomic RNAs. Our data indicate that about 70% of the SFFV sequence is a perfect copy of parts of the helper genome. We conclude that our SFFV and LLV isolates have co-evolved very closely and that SFFV-specific sequences are not identical in different Friend virus isolates.

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1981-06-01
2021-10-25
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References

  1. Axelrad A. A., Steeves R. A. 1964; Assay for Friend leukemia virus: rapid quantitative method based on enumeration of macroscopic spleen foci in mice. Virology 24:513–518
    [Google Scholar]
  2. Bailey J. M., Davidson N. 1976; Methylmercury as a reversible denaturing agent for agarose gel electrophoresis. Analytical Biochemistry 70:75–85
    [Google Scholar]
  3. Beemon K. L., Faras A. J., Haase A. T., Duesberg P. H., Maisel J. E. 1975; Genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis and visna viruses. Journal of Virology 17:525–537
    [Google Scholar]
  4. Bernstein A., Mak T. W., Stevenson J. R. 1977; The Friend spleen focus-forming virus (SFFV) genome: evidence for the stable association of MuLV sequences and sequences involved in erythroleukemic transformation. Cell 12:287–294
    [Google Scholar]
  5. Bernstein A., Gamble C., Penrose D., Mak T. W. 1979; Presence and expression of Friend erythroleukemia virus-related sequences in normal and leukemic mouse tissues. Proceedings of the National Academy of Sciences of the United States of America 76:4455–4459
    [Google Scholar]
  6. Besmer P., Olshevsk L. U., Baltimore D., Fan H. 1979; Virus-like 30S RNA in mouse cells. Journal of Virology 29:1168–1176
    [Google Scholar]
  7. Bilello J. A., Colletta G., Warnecke G., Koch G., Frisby D., Pragnell I. B., Ostertag W. 1980; Analysis of the expression of SFFV-related RNA and gp 55 a Friend and Rauscher virus specific protein. Virology 107:331–344
    [Google Scholar]
  8. Bosselman R. A., Van Griensven L. J. L. D., Vogt M., Verma I. M. 1980; Genome organization of retroviruses. IX. Analysis of the genomes of Friend spleen focus-forming virus (F-SFFV) and helper murine leukemia viruses by heteroduplex-formation. Virology 102:234–239
    [Google Scholar]
  9. Coffin J. M., Billeter M. A. 1976; A physical map of the Rous sarcoma virus genome. Journal of Molecular Biology 100:293–318
    [Google Scholar]
  10. Coffin J. M., Hageman T. C., Maxam A. M., Haseltine W. A. 1978; Structure of the genome of Moloney murine leukemia virus: a terminally redundant sequence. Cell 13:761–773
    [Google Scholar]
  11. Duesberg P. H., Scolnick E. M. 1977; Murine leukemia viruses containing a 30S RNA subunit of unknown biological activity, in addition to the 38S subunit of the viral genome. Virology 83:211–216
    [Google Scholar]
  12. Evans L. H., Duesberg P. H., Troxler D. H., Scolnick E. M. 1979; Spleen focus-forming Friend virus: identification of genomic RNA and its relationship to helper virus RNA. Journal of Virology 31:133–146
    [Google Scholar]
  13. Evans L., Nunn M., Duesberg P., Troxler D., Scolnick E. 1980; The RNAs of the defective and non-defective components of the FVA and FVP strains identified and compared. Cold Spring Harbor Symposia on Quantitative Biology 44:823–835
    [Google Scholar]
  14. Faller D. V., Hopkins N. 1978; T1 oligonucleotide maps of Moloney and HIX murine leukemia viruses. Virology 90:265–273
    [Google Scholar]
  15. Friend C., Scher W., Tsuei D., Haddad J., Holland J. G., Szrajer N., Haubenstock H. 1979; Perspectives on Friend leukemia virus: pathogenesis in vivo and studies on the control of erythrodifferentiation. In Oncogenic viruses and Host Cell Genes pp 279–301 Edited by Ikawa Y., Odaka T. New York: Academic Press;
    [Google Scholar]
  16. Mak T. W., Penrose D., Gamble C., Bernstein A. 1978; Friend spleen focus-forming virus (SFFV) genome: fractionation and analysis of SFFV and helper virus-related sequences. Virology 87:73–80
    [Google Scholar]
  17. Ostertag W., Pragnell I. B. 1978; Changes in genome composition of the Friend virus complex in erythroleukemia cells during the course of differentiation induced by dimethyl sulphoxide. Proceedings of the National Academy of Sciences of the United States of America 75:3278–3282
    [Google Scholar]
  18. Ostertag W., Pragnell I. B. 1981; Retrovirus expression in murine erythroleukemia. Current Topics in Microbiology and Immunology (in press)
    [Google Scholar]
  19. Pragnell I. B., Mcnab A., Harrison P. R., Ostertag W. 1978; Are spleen focus-forming virus sequences related to xenotropic viruses and expressed specifically in normal erythroid cells?. Nature, London 272:456–458
    [Google Scholar]
  20. Pragnell I. B., Ostertag W., Paul J., Williamson R. 1979; The Friend virus genome: partial characterization of a complete DNA copy. Journal of General Virology 43:1–14
    [Google Scholar]
  21. Rommelaere J., Faller D. V., Hopkins N. 1978; Characterization and mapping of RNAase Tl-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses. Proceedings of the National Academy of Sciences of the United States of America 75:495–499
    [Google Scholar]
  22. Steeves R. A. 1975; Spleen focus-forming virus in Friend and Rauscher leukemia virus preparations. Journal of the National Cancer Institute 54:289–294
    [Google Scholar]
  23. Steeves R. A., Eckner R. J., Bennett M., Mirand E. A., Trudel P. J. 1971; Isolation and characterization of a lymphatic leukemia virus in the Friend virus complex. Journal of the National Cancer Institute 46:1209–1217
    [Google Scholar]
  24. Troxler D. H., Scolnick E. M. 1978; Rapid leukemia induced by cloned Friend strain of replicating murine type C virus. Virology 85:17–27
    [Google Scholar]
  25. Troxler D. H., Parks W. P., Vass W. C., Scolnick E. M. 1977a; Isolation of a fibroblast non-producer cell line containing the Friend strain of the spleen focus-forming virus. Virology 76:602–615
    [Google Scholar]
  26. Troxler D. H., Lowy D., Howk R., Young H., Scolnick E. M. 19775; Friend strain of spleen focus-forming virus is a recombinant between ecotropic murine type C virus and the env gene region of xenotropic type C virus. Proceedings of the National Academy of Sciences of the United States of America 74:4671–4675
    [Google Scholar]
  27. Van Griensven L. J. L. D., Vogt M. 1980; Rauscher ‘mink cell focus-inducing’ (MCF) virus causes erythroleukemia in mice: its isolation and properties. Virology 101:376–388
    [Google Scholar]
  28. Wang L. H., Duesberg P. H., Beemon K., Vogt P. K. 1975; Mapping RNase Tl-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end. Journal of Virology 16:1051–1070
    [Google Scholar]
  29. Yoshida M., Yoshikura H. 1980; Analysis of spleen focus-forming virus-specific RNA sequences coding for spleen focus-forming virus-specific glycoprotein with a molecular weight of 55000 (gp55). Journal of Virology 33:587–596
    [Google Scholar]
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