@article{mbs:/content/journal/jgv/10.1099/0022-1317-54-2-293, author = "Kato, Tsuneo and Minagawa, Tomonori", title = "Cellular Source of Interferon Induced in Human Peripheral Blood Mononuclear Leukocytes by Mumps Virus or by Tumour Cells Persistently Infected with Mumps Virus", journal= "Journal of General Virology", year = "1981", volume = "54", number = "2", pages = "293-299", doi = "https://doi.org/10.1099/0022-1317-54-2-293", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-54-2-293", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY Human leukocyte interferon (IFN-α) was induced in cultures of human peripheral blood mononuclear leukocytes (PBML) from seropositive healthy donors infected by mumps virus, or by a human lung carcinoma cell line (Pc-10) persistently infected with mumps virus (Pc-10/MpV). Adherent cells (Mϕ), non-T, non-B cells and B cells all produced IFN in response to mumps virus or Pc-10/MpV cells. The non-T, non-B cells co-cultured with Pc-10/MpV cells produced high-titred IFN. However, T cells did not produce any antiviral factors even in the presence of Mϕ. Furthermore, T cells activated with phytohaemagglutinin (PHA-P), concanavalin A or treated with u.v.-irradiated mumps virus, or Pc-10/MpV cells pretreated with mitomycin C did not produce any antiviral factors in response to either mumps virus or Pc-10/MpV cells.", }