RT Journal Article SR Electronic(1) A1 Traub, Abraham A1 Payess, Benjamin A1 Reuveny, Shaul A1 Mizrahi, AvshalomYR 1981 T1 Interferon-Albumin Conjugate with Conserved Biological Activity JF Journal of General Virology, VO 53 IS 2 SP 389 OP 392 DO https://doi.org/10.1099/0022-1317-53-2-389 PB Microbiology Society, SN 1465-2099, AB SUMMARY The heterobifunctional reagent N-succinilimidyl 3-(2-pyridylthio)propionate (SPDP) was used for the preparation of a disulphide-linked conjugate between Namalwa lymphoblastoid interferon and serum albumin. The linkage of interferon to albumin did not reduce its ability to protect MDBK cells against infection by vesicular stomatitis virus (VSV). The conjugate did not dissociate into free interferon and albumin under conditions prevailing in the assay for interferon activity. The rate of clearance of the interferon-albumin conjugate from the mouse circulatory system was somewhat slower than that of free interferon., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-53-2-389