The pp60 kinase activity of cells infected with temperature-conditional mutants of Rous sarcoma virus (RSV), which induce only a partial transformation, was compared to the pattern of transformation parameters induced by these mutants. The GI251-infected cells were thermosensitive for hexose transport, fibrinolysis, morphological alterations and pp60 kinase activity, but cold-sensitive for loss of growth control. The GI253-infected cells were similar to GI251-infected cells except that they were only slightly cold-sensitive for loss of growth control and had a very low pp60 kinase activity which was temperature-insensitive. Thus, the pp60 kinase activity measured with IgG as a substrate did not correlate in a consistent way with any of the measured parameters of transformation.


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