1887

Abstract

Summary

Interferon induces an activity which strongly inhibits the growth of -1, an interferon-response mutant of mengovirus. This activity is not expressed in protected cells infected with either (the wild-type parent) or vaccinia virus, or in cells infected with -1 in the presence of actinomycin D. A failure of -1 to shut off host RNA and/or protein synthesis could explain these observations. The present paper, however, shows that -1 and are equally effective in suppressing host syntheses, and suggests that actively inhibits the interferon-mediated activity directed against -1.

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/content/journal/jgv/10.1099/0022-1317-52-2-391
1981-02-01
2019-11-22
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-52-2-391
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