RT Journal Article SR Electronic(1) A1 Mayo, Donald R. A1 Rapp, FredYR 1980 T1 Leukaemia Reactivates Mouse Cytomegalovirus JF Journal of General Virology, VO 51 IS 2 SP 401 OP 404 DO https://doi.org/10.1099/0022-1317-51-2-401 PB Microbiology Society, SN 1465-2099, AB SUMMARY An established model for latency by mouse cytomegalovirus (MCMV) was used to assess the effects of leukaemia on reactivation of MCMV. After inoculation of 400 spleen focus-forming units of Friend leukaemia virus (FLV), a significant number of mice yielded MCMV in salivary glands and kidneys 4 to 5 weeks later. Administration of cyclophosphamide during FLV infection increased the percentage of MCMV-positive animals. These results suggest that cytomegalovirus infections in leukaemia patients may reactivate as a result of the leukaemia itself and may be exacerbated by chemotherapy., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-51-2-401