%0 Journal Article %A Mayo, Donald R. %A Rapp, Fred %T Leukaemia Reactivates Mouse Cytomegalovirus %D 1980 %J Journal of General Virology, %V 51 %N 2 %P 401-404 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-51-2-401 %I Microbiology Society, %X SUMMARY An established model for latency by mouse cytomegalovirus (MCMV) was used to assess the effects of leukaemia on reactivation of MCMV. After inoculation of 400 spleen focus-forming units of Friend leukaemia virus (FLV), a significant number of mice yielded MCMV in salivary glands and kidneys 4 to 5 weeks later. Administration of cyclophosphamide during FLV infection increased the percentage of MCMV-positive animals. These results suggest that cytomegalovirus infections in leukaemia patients may reactivate as a result of the leukaemia itself and may be exacerbated by chemotherapy. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-51-2-401