@article{mbs:/content/journal/jgv/10.1099/0022-1317-51-2-401, author = "Mayo, Donald R. and Rapp, Fred", title = "Leukaemia Reactivates Mouse Cytomegalovirus", journal= "Journal of General Virology", year = "1980", volume = "51", number = "2", pages = "401-404", doi = "https://doi.org/10.1099/0022-1317-51-2-401", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-51-2-401", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY An established model for latency by mouse cytomegalovirus (MCMV) was used to assess the effects of leukaemia on reactivation of MCMV. After inoculation of 400 spleen focus-forming units of Friend leukaemia virus (FLV), a significant number of mice yielded MCMV in salivary glands and kidneys 4 to 5 weeks later. Administration of cyclophosphamide during FLV infection increased the percentage of MCMV-positive animals. These results suggest that cytomegalovirus infections in leukaemia patients may reactivate as a result of the leukaemia itself and may be exacerbated by chemotherapy.", }