1887

Abstract

SUMMARY

An established model for latency by mouse cytomegalovirus (MCMV) was used to assess the effects of leukaemia on reactivation of MCMV. After inoculation of 400 spleen focus-forming units of Friend leukaemia virus (FLV), a significant number of mice yielded MCMV in salivary glands and kidneys 4 to 5 weeks later. Administration of cyclophosphamide during FLV infection increased the percentage of MCMV-positive animals. These results suggest that cytomegalovirus infections in leukaemia patients may reactivate as a result of the leukaemia itself and may be exacerbated by chemotherapy.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-51-2-401
1980-12-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/51/2/JV0510020401.html?itemId=/content/journal/jgv/10.1099/0022-1317-51-2-401&mimeType=html&fmt=ahah

References

  1. Abdallah P. S., Mark J. B. D., Merigan T. C. 1976; Diagnosis of cytomegalovirus pneumonia in comprised hosts. American Journal of Medicine 61:326–332
    [Google Scholar]
  2. Axelrad A. A., Steeves R. A. 1964; Assay for Friend leukemia virus: rapid quantitative method based on enumeration of macroscopic spleen foci in mice. Virology 24:513–518
    [Google Scholar]
  3. Betts R. F., Hanshaw J. B. 1977; Cytomegalovirus (CMV) in the compromised host(s). Annual Review of Medicine 28:103–110
    [Google Scholar]
  4. Ceglowski W. S., Campbell B. P., Mortensen R. F., Friedman H. 1974; Humoral and cellular immune responses in susceptible and resistant strains of mice infected with Friend leukemia virus (38159). Proceedings of the Society for Experimental Biology and Medicine 146:619–624
    [Google Scholar]
  5. Cheung K.-S., Lang D. J. 1977; Transmission and activation of cytomegalovirus with blood transfusion: a mouse model. Journal of Infectious Diseases 135:841–845
    [Google Scholar]
  6. Eckner R. J. 1973; Helper-dependent properties of Friend spleen focus forming virus: effect of the Fv-1 gene on the late stages in virus synthesis. Journal of Virology 12:523–533
    [Google Scholar]
  7. Ho M. 1977; Virus infections after transplantation in man. Brief review. Archives of Virology 55:1–24
    [Google Scholar]
  8. Hudson J. B., Chantler J. K., Loh L., Misra V., Muller M. T. 1979; Model systems for analysis of latent cytomegalovirus infections. Canadian Journal of Microbiology 25:245–253
    [Google Scholar]
  9. Jordan M. C., Shanley J. D., Stevens J. G. 1977; Immunosuppression reactivates and disseminates latent murine cytomegalovirus. Journal of General Virology 37:419–423
    [Google Scholar]
  10. Levine A. S., Schimpff S. C., Graw R. G., Young R. C. 1974; Hematologic malignancies and other marrow failure states: progress in the management of complicating infections. Seminars in Hematology 11:141–202
    [Google Scholar]
  11. Lilly F., Pincus T. 1973; Genetic control of murine viral leukemogenesis. Advances in Cancer Research 17:231–277
    [Google Scholar]
  12. Mayo D. R., Rapp F. 1980; Acute cytomegalovirus infections in leukemic mice. Infection and Immunity 29:311–315
    [Google Scholar]
  13. Mayo D. R., Armstrong J. A., Ho M. 1977; Reactivation of murine cytomegalovirus by cyclophosphamide. Nature, London 267:721–723
    [Google Scholar]
  14. Mayo D. R., Armstrong J. A., Ho M. 1978; Activation of latent murine cytomegalovirus infection: cocultivation, cell transfer and the effect of immunosuppression. Journal of Infectious Diseases 138:890–896
    [Google Scholar]
  15. Olding L. B., Jensen F. C., Oldstone M. B. A. 1975; Pathogenesis of cytomegalovirus infection. I. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction. Journal of Experimental Medicine 141:561–572
    [Google Scholar]
  16. Wise T. G., Manischewitz J. E., Quinnan G. V., Aulakh G. S., Ennis F. A. 1979; Latent cytomegalovirus infection of BALB/c mouse spleens detected by an explant culture technique. Journal of General Virology 44:551–556
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-51-2-401
Loading
/content/journal/jgv/10.1099/0022-1317-51-2-401
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error