Murine cytomegalovirus (MCMV) may be rapidly and reproducibly attenuated by passage in tissue culture. A high proportion of CDI mice neonatally infected with the virulent strain of CMV can be shown to have replicating virus in the kidneys for up to 90 weeks p.i. and this high rate of isolation is not altered in pregnancy. A much lower rate of isolation from the kidneys is seen in CDI mice neonatally infected with the attenuated strain. However, this isolation rate was significantly increased during pregnancy and higher titres of virus were recovered.


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  1. Jordan M. C., Stanley J. D., Stevens J. G. 1977; Immunosuppression reactivates and disseminates latent murine cytomegalovirus. Journal of General Virology 37:419–423
    [Google Scholar]
  2. Lang D. J. 1972; Cytomegalovirus infections in organ transplantation and host transfusion. Archiv füir die gesamte Virusforschung 37:365–377
    [Google Scholar]
  3. Medearis D. N. 1964; Mouse cytomegalovirus infection. II. Observations during prolonged infection. American Journal of Hygiene 80:103–112
    [Google Scholar]
  4. Mims C. A., Gould J. J. 1978; The role of macrophages in mice infected with murine cytomegalovirus. Journal of General Virology 41:143–153
    [Google Scholar]
  5. Olding L. B., Jensen F. C., Oldstone M. B. A. 1975; Pathogenesis of cytomegalovirus infection. 1. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction. Journal of Experimental Medicine 141:561–572
    [Google Scholar]
  6. Reynolds D. W., Stagno S., Hosty T. S., Tiller M., Alford C. A. Jr 1973; Maternal cytomegalovirus excretion and perinatal infection. New England Journal of Medicine 289:1–5
    [Google Scholar]

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