1887

Abstract

SUMMARY

Latent infections have been established in cervical dorsal root ganglia of Balb/c mice following peripheral inoculation of mutants of HSV-1. Activation of the mutant LS2 at the non-permissive temperature by culture of excised ganglia, or by neurosurgery has allowed the unambiguous identification of the neuron as the site of latent infection. Evidence is presented which shows that activation of virus infection in latently infected ganglia by neurosurgery results in a reduction of the number of latent foci in that ganglion. One interpretation of this observation is that the productive infection which follows activation of latent virus in the neuron leads to the destruction of that cell.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-51-2-233
1980-12-01
2022-01-18
Loading full text...

Full text loading...

/deliver/fulltext/jgv/51/2/JV0510020233.html?itemId=/content/journal/jgv/10.1099/0022-1317-51-2-233&mimeType=html&fmt=ahah

References

  1. Baringer J. R., Swoveland P. 1973; Recovery of herpes simplex virus from human trigeminal ganglions. New England Journal of Medicine 388:648–650
    [Google Scholar]
  2. Carton C. A., Kilbourne E. D. 1952; Activation of latent herpes simplex by trigeminal sensory root section. New England Journal of Medicine 346:172–176
    [Google Scholar]
  3. Cook M. L., Stevens J. G. 1973; Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infection and Immunity 7:272–288
    [Google Scholar]
  4. Cook M. L., Bastone V. B., Stevens J. G. 1974; Evidence that neurons harbor latent herpes simplex virus. Infection and Immunity 9:946–951
    [Google Scholar]
  5. Field H. J., Bell S. E., Elion G. B., Nash A. A., Wildy P. 1979; Effect of acycloguanosine treatment on acute and latent herpes simplex infections in mice. Antimicrobial Agents and Chemotherapy 15:554–561
    [Google Scholar]
  6. Halliburton I. W., Randall R. E., Killington R. A., Watson D. H. 1977; Some properties of intertypic recombinants between type 1 and type 2 herpes simplex virus. Journal of General Virology 36:471–484
    [Google Scholar]
  7. Hill T. J., Field H. J., Roome A. P. C. 1972; Intra-axonal location of herpes simplex virus particles. Journal of General Virology 15:253–255
    [Google Scholar]
  8. Hill T. J., Field H. J., Blyth W. A. 1975; Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. Journal of General Virology 38:341–353
    [Google Scholar]
  9. Klein R. J. 1976; Pathogenic mechanisms of recurrent herpes simplex infections. Archives of Virology 51:1–13
    [Google Scholar]
  10. Lieberman A. R. 1971; The axon reaction: a review of the principal features of perikaryl responses to axon injury. International Review of Neurobiology 14:49–124
    [Google Scholar]
  11. Lofgren K. W., Stevens J. G., Marsden H. S., Subak-sharpe J. H. 1977; Temperature sensitive mutants of herpes simplex virus differ in the capacity to establish latent infections in mice. Virology 76:440–443
    [Google Scholar]
  12. Price R. W., Schmitz J. 1978; Reactivation of latent herpes simplex virus infection of the autonomic nervous system by postganglionic neurectomy. Infection and Immunity 19:523–532
    [Google Scholar]
  13. Stevens J. G., Cook M. L. 1971; Latent herpes simplex virus in spinal ganglia of mice. Science 173:843–845
    [Google Scholar]
  14. Walz M. A., Price R. W., Notkins A. L. 1974; Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. Science 184:1185–1187
    [Google Scholar]
  15. Watson D. H., Shedden W. I. H., Elliot A., Tetsuka T., Wildy P., Borgaux-ramoisy D., Gold E. 1966; Virus specific antigens in mammalian cells infected with herpes simplex virus. Immunology 11:399–408
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-51-2-233
Loading
/content/journal/jgv/10.1099/0022-1317-51-2-233
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error