1887

Abstract

SUMMARY

Intact 146S particles of the seven serotypes of foot-and-mouth disease virus (FMDV) produce type-specific precipitating, complement-fixing and neutralizing antibodies in cattle and guinea-pigs. However, the 12S structural subunit, produced from the virus particle by mild acid treatment (pH 6) or by heating at 56 °C, although stimulating the production of precipitating and complement-fixing antibodies, produces only low levels of neutralizing antibody. Nevertheless, 12S particles were as active as 146S particles in stimulating the production of neutralizing antibody in guinea-pigs primed with a vaccine prepared from 146S particles. Moreover, heterotypic 12S and 146S particles also boosted the neutralizing antibody response to the first virus. These results point to an antigenic similarity between the 146S particles of each type and to a close antigenic relationship between the 146S and 12S particles.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-50-2-369
1980-10-01
2021-10-21
Loading full text...

Full text loading...

/deliver/fulltext/jgv/50/2/JV0500020369.html?itemId=/content/journal/jgv/10.1099/0022-1317-50-2-369&mimeType=html&fmt=ahah

References

  1. Bachrach H. L., Moore D. M., Mckercher P. D., Polatnick J. 1975; Immune and antibody responses to an isolated capsid protein of foot-and-mouth disease virus. Journal of Immunology 115:1636–1641
    [Google Scholar]
  2. Brown F., Cartwright B. 1963; Purification of radioactive foot-and-mouth disease virus. Nature, London 199:1168–1170
    [Google Scholar]
  3. Brown F., Crick J. 1959; Application of agar gel diffusion analysis to a study of the antigenic structure of inactivated vaccines prepared from the virus of foot-and-mouth disease. Journal of Immunology 82:444–447
    [Google Scholar]
  4. Burroughs J. N., Rowlands D. J., Sangar D. V., Talbot P., Brown F. 1971; Further evidence for multiple proteins in the foot-and-mouth disease particle. Journal of General Virology 13:73–84
    [Google Scholar]
  5. Cartwright B. 1962; A study of the antibodies in guinea pigs infected with foot-and-mouth disease virus. Journal of Immunology 88:128–133
    [Google Scholar]
  6. Ceglowski W. S. 1965; Antibody response to the noninfectious 7mµ component of the virus of foot-and-mouth disease. Virology 25:328–330
    [Google Scholar]
  7. Dunker A. K. 1979; The structure of picornaviruses: classification of the bonding networks. Virology 97:141–150
    [Google Scholar]
  8. Hordern J. S., Leonard J. D., Scraba D. G. 1979; Structure of the Mengo virion. VI. Spatial relationships of the capsid polypeptides as determined by chemical cross-linking analyses. Virology 97:131–140
    [Google Scholar]
  9. Kaaden O. R., Adam K. H., Strohmaier K. 1977; Induction of neutralizing antibodies and immunity in vaccinated guinea pigs by cyanogen bromide peptides of VP3 of foot-and-mouth disease virus. Journal of General Virology 34:397–400
    [Google Scholar]
  10. Laporte J., Grosclaude J., Wantyghem J., Bernard S., Rouze P. 1973; NeutraliSAT1on en culture cellulaire du pouvoir infectieux du virus de la fievre aphteuse par des serums provenant de pores immunises a I’aide d’une proteine virale purifiee. Comptes rendus hebdomadaires des Seances de l’ Academic des Sciences 276D:3399–3401
    [Google Scholar]
  11. Meloen R. H., Rowlands D. J., Brown F. 1979; Comparison of the antibodies elicited by the individual structural polypeptides of foot-and-mouth disease and polio viruses. Journal of General Virology 45:761–763
    [Google Scholar]
  12. Newman J. F. E., Cartwright B., Doel T. R., Brown F. 1979; Purification and identification of the RNA-dependent RNA polymerase of foot-and-mouth disease virus. Journal of General Virology 45:497–507
    [Google Scholar]
  13. Robson K. J. H., Harris T. J. R., Brown F. 1977; An assessment by competition hybridization of the sequence homology between the RNAs of the seven serotypes of FMDV. Journal of General Virology 37:271–276
    [Google Scholar]
  14. Rowlands D. J., Sangar D. V., Brown F. 1971; Relationship of the antigenic structures of foot-and-mouth disease virus to the process of infection. Journal of General Virology 13:85–93
    [Google Scholar]
  15. Wardley R. C., Chapman W. G., Garland A. J. M. 1979; A blastogenic test for foot-and-mouth disease. Journal of Hygiene 83:507–512
    [Google Scholar]
  16. Wild T. F., Brown F. 1967; Nature of the inactivating action of trypsin on foot-and-mouth disease virus. Journal of General Virology 1:247–250
    [Google Scholar]
  17. Wild T. F., Burroughs J. N., Brown F. 1969; Surface structure of foot-and-mouth disease virus. Journal of General Virology 4:313–320
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-50-2-369
Loading
/content/journal/jgv/10.1099/0022-1317-50-2-369
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error