1887

Abstract

SUMMARY

This study describes the biological properties of a strain of virus isolated from tissues of a goat with leukoencephalomyelitis–arthritis. The agent is a retrovirus, having a virion-associated reverse transcriptase enzyme and an antigenic determinant(s) which cross-reacts with the p30 of visna–maedi viruses. Morphogenesis of the virus is also similar to visna virus in terms of virus assembly and the multinucleated giant cell formation which accompanies replication of the latter virus. Despite its cytopathogenic property the goat agent was not lytic in goat cell culture, causing instead a productive infection which persisted through multiple subcultures of the cells. The virus replicated incompletely in sheep cell cultures but could be rescued from the latter, weeks after inoculation, by co-cultivation with goat cells. Our data suggest that this strain of goat leukoencephalitis virus is a variant of the ovine retroviruses with a host range limited to the goat.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-50-1-69
1980-09-01
2024-04-24
Loading full text...

Full text loading...

/deliver/fulltext/jgv/50/1/JV0500010069.html?itemId=/content/journal/jgv/10.1099/0022-1317-50-1-69&mimeType=html&fmt=ahah

References

  1. Cork L. C., Narayan O. 1980; The pathogenesis of viral leukoencephalomyelitis-arthritis of goats. I. Persistent viral infection with progressive pathologic changes. Laboratory Investigation 42:596–602
    [Google Scholar]
  2. Cork L. C., Hadlow W. J., Gorham J. R., Piper R. C., Crawford T. B. 1974a; Pathology of viral leukoencephalomyelitis of goats. Acta Neuropathologica 29:281–292
    [Google Scholar]
  3. Cork L. C., Hadlow W. J., Crawford T. B., Gorham J. R., Piper R. C. 1974b; Infectious leukoencephalomyelitis of young goats. Journal of Infectious Diseases 129:134–141
    [Google Scholar]
  4. Coward J. E., Harter D. H., Morgan C. 1970; Electron microscopic observations of visna virus-infected cell cultures. Virology 40:1030–1038
    [Google Scholar]
  5. Haase A. T., Baringer J. R. 1974; The structural polypeptides of RNA slow viruses. Virology 57:238–250
    [Google Scholar]
  6. Harter D. H., Coward J. E. 1974; Sheep progressive pneumonia virus: ‘slow’ cytolytic agents with tumor virus properties. Texas Reports on Biology and Medicine 32:649–664
    [Google Scholar]
  7. Naravan O., Griffin D. E., Silverstein A. M. 1977; Slow virus infections: replication and mechanisms of persistence of visna virus in sheep. Journal of Infectious Diseases 135:800–806
    [Google Scholar]
  8. Narayan O., Griffin D. E., Clements J. E. 1978; Virus mutation during ‘slow infection’: temporal development and characterization of mutants of visna virus recovered from sheep. Journal of General Virology 41:343–352
    [Google Scholar]
  9. O’Sullivan B. M., Eaves F. W., Baxendell S. A., Rowan K. J. 1978; Leukoencephalomyelitis of goat kids. Australian Veterinary Journal 54:479–483
    [Google Scholar]
  10. Petursson G., Nathanson N., Georgsson G., Panitch H., Palsson P. A. 1976; Pathogenesis of visna. I. Sequential virology, serologic and pathologic studies. Laboratory Investigation 35:402–412
    [Google Scholar]
  11. Sigurdsson B., Grimssom H., Palsson P. A. 1952; Maedi, a chronic progressive infection of sheep’s lung. Journal of Infectious Diseases 90:233–241
    [Google Scholar]
  12. Sigurdsson B., Palsson P. A., Grimssom H. 1957; Visna, a demyelinating transmissable disease of sheep. Journal of Neuropathology and Experimental Neurology 16:389–403
    [Google Scholar]
  13. Stavrou D., Deutschlander N., Dahme E. 1969; Granulomatous encephalomyelitis in goats. Journal of Comparative Pathology 79:393–396
    [Google Scholar]
  14. Stowring L., Haase A. T., Charman H. P. 1979; Serologic definition of the lenti virus group of retroviruses. Journal of Virology 29:523–528
    [Google Scholar]
  15. Thormar H. 1965; Physical, chemical and biological properties of visna virus and its relationship to other animal viruses. NINDB Monograph No. 2. Slow Latent and Temperate Virus Infections Washington, D.C.: pp 335–340
    [Google Scholar]
  16. Thormar H., Helgadottir H. 1965; A comparison of visna and maedi viruses. II. Serological relationships. Research in Veterinary Science 6:456–465
    [Google Scholar]
  17. Thormar H., Palsson P. A. 1967; Visna and maedi - two slow infections of sheep and their etiological agents. Perspectives in Virology 5:291–308
    [Google Scholar]
  18. Weinhold E. 1974; Visna-virus-ahnliche partikel in der Kultur von Plexus choriodeus-zellen einer Ziege mit Visna-symptomen. Zentralblatt fur Veterinarmedizin 21B:32–36
    [Google Scholar]
  19. Wynne-Roberts C. R., Anderson C. H., Turano A. M., Baron M. 1978; Light and electron microscopic findings of juvenile rheumatoid arthritis synovium: comparison with normal juvenile synovium. Seminars in Arthritis and Rheumatism 7:287–302
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-50-1-69
Loading
/content/journal/jgv/10.1099/0022-1317-50-1-69
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error