Inborn resistance to orthomyxoviruses due to the allele was investigated at the molecular level in macrophages from A2G mice. In the absence of interferon, -bearing and control cells were equally permissive for M-TUR, a macrophage-adapted strain of influenza A virus. After treatment with various doses of mouse interferon type I, -bearing cells were fully resistant to this virus whereas cells lacking were only marginally protected. Virus attachment and penetration were equally efficient in -carrying and control cells and were not influenced by interferon. However, virus protein synthesis was blocked in -bearing macrophages expressing resistance. These findings indicate that the resistance mechanism specific for influenza viruses realized by in cooperation with interferon inhibits influenza virus replication in macrophages at an early stage following attachment and penetration of the virus.


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