1887

Abstract

SUMMARY

Inborn resistance to orthomyxoviruses due to the allele was investigated at the molecular level in macrophages from A2G mice. In the absence of interferon, -bearing and control cells were equally permissive for M-TUR, a macrophage-adapted strain of influenza A virus. After treatment with various doses of mouse interferon type I, -bearing cells were fully resistant to this virus whereas cells lacking were only marginally protected. Virus attachment and penetration were equally efficient in -carrying and control cells and were not influenced by interferon. However, virus protein synthesis was blocked in -bearing macrophages expressing resistance. These findings indicate that the resistance mechanism specific for influenza viruses realized by in cooperation with interferon inhibits influenza virus replication in macrophages at an early stage following attachment and penetration of the virus.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-50-1-205
1980-09-01
2022-11-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/50/1/JV0500010205.html?itemId=/content/journal/jgv/10.1099/0022-1317-50-1-205&mimeType=html&fmt=ahah

References

  1. Arnheiter H., Haller O., Lindenmann J. 1980; Host gene influence on interferon action in adult mouse hepatocytes: specificity for influenza virus. Virology 103:11–20
    [Google Scholar]
  2. Bean W. J., Simpson R. W. 1973; Primary transcription of the influenza virus genome in permissive cells. Virology 56:646–651
    [Google Scholar]
  3. Bosch F. X., Hay A., Skehel J. J. 1978; RNA and protein synthesis in a permissive and an abortive influenza infection. In Negative Strand Viruses and the Host Celt pp 465–474 Edited by Mahy B. W. J., Barry R. D. London and New York: Academic Press;
    [Google Scholar]
  4. Chairez R., Yoon J.-W., Notkins A. L. 1978; Virus-induced diabetes mellitus. X. Attachment of encephalomyocarditis virus and permissiveness of cultured pancreatic β cells to infection. Virology 85:606–611
    [Google Scholar]
  5. Franklin R. M., Breitenfeld P. M. 1959; The abortive infection of Earle’s L-cells by fowl plague virus. Virology 8:293–307
    [Google Scholar]
  6. Galster R. L., Lengyel P. 1976; Formation and characteristics of reovirus subviral particles in interferon-treated mouse L cells. Nucleic Acids Research 3:581–598
    [Google Scholar]
  7. Gresser I. 1977; Commentary on the varied biological effects of interferon. Cellular Immunology 34:406–415
    [Google Scholar]
  8. Haller O., Arnheiter H., Gresser I., Lindenmann J. 1979; Genetically determined, interferon-dependent resistance to influenza virus in mice. Journal of Experimental Medicine 149:601–612
    [Google Scholar]
  9. Haller O., Arnheiter H., Lindenmann J., Gresser L. 1980; Flost gene influences sensitivity to interferon action selectively for influenza virus. Nature, London 283:660–662
    [Google Scholar]
  10. Horisberger M. A., Schulze C. 1974; Properties of an RNA polymerase complex detected in influenza virus-infected cells. Archiv für die gesamte Virusforschung 46:148–155
    [Google Scholar]
  11. Laemmli U. K., Favre M. 1973; Maturation of the head of bacteriophage T4. I. DNA packaging events. Journal of Molecular Biology 80:575–599
    [Google Scholar]
  12. Lindenmann J., Deuel E., Fanconi S., Haller O. 1978; Inborn resistance of mice to myxoviruses: macrophages express phenotype in vitro. Journal of Experimental Medicine 147:531–540
    [Google Scholar]
  13. Lohmeyer J., Talens L. T., Klenk H. D. 1979; Biosynthesis of the influenza virus envelope in abortive infection. Journal of General Virology 42:73–88
    [Google Scholar]
  14. Repik P., Flamand A., Bishop D. H. L. 1974; Effect of interferon upon primary and secondary transcription of vesicular stomatitis and influenza viruses. Journal of Virology 14:1169–1178
    [Google Scholar]
  15. Ter Meulen V., Love R. 1967; Virological, immunochemical and cytochemical studies of four HeLa-cell lines infected with two strains of influenza virus. Journal of Virology 1:626–639
    [Google Scholar]
  16. Tovey M. G., Begon-Lours J., Gresser L. 1974; A method for the scale production of potent interferon preparations. Proceedings of the Society for Experimental Biology and Medicine 146:809–815
    [Google Scholar]
  17. Wiebe M. E., Joklik W. K. 1975; The mechanism of inhibition of reovirus replication by interferon. Virology 66:229–240
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-50-1-205
Loading
/content/journal/jgv/10.1099/0022-1317-50-1-205
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error