1887

Abstract

There are many reports in the literature indicating that the administration of exogenous interferon or induction of endogenous interferon can protect experimental animals against certain virus infections (reviewed by Finter, 1966, and Vilcek, 1969). In most of these studies, challenge was by parenteral inoculation of relatively large quantities of virus and the protective effects of interferon were assessed in terms of decreased mortality or less severe disease. However, naturally acquired virus infection is generally the consequence of exposure to much smaller quantities of virus, and with respiratory viruses, infection is initiated by deposition of virus in appropriate areas of the respiratory tract and not by parenteral inoculation. Accordingly, experiments were designed to determine whether interferon induced by Newcastle disease virus (NDV) could protect mice from infection by influenza virus transmitted by other mice. This experimental system was described in detail by Schulman & Kilbourne (1963) and was used to study the effects on transmission of infection of other modifications of the host such as immunization (Schulman, 1967).

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-5-3-429
1969-10-01
2022-06-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/5/3/JV0050030429.html?itemId=/content/journal/jgv/10.1099/0022-1317-5-3-429&mimeType=html&fmt=ahah

References

  1. Finter N. B. 1966; Interferons in animals and man. In the Frontiers of Biology Vol. 2 Interferons pp. 232–67 Ed. by Finter N. B. Amsterdam: North-Holland Publishing Co;
    [Google Scholar]
  2. Finter N. B. 1967 Of mice and man: studies with interferon. In the Ciba Foundation Symposium: Interferon pp. 204–15 Ed. by Wolstenholme G. E. W., O’Connor M. Boston, Mass: Little, Brown and Co;
    [Google Scholar]
  3. Rytel M. W., Kilbourne E. D. 1966; The influence of cortisone on experimental viral infection. VIII. Suppression by cortisone of interferon formation in mice injected with Newcastle disease virus. J. exp. Med 123:767
    [Google Scholar]
  4. Schulman J. L., Kilbourne E. D. 1963; Experimental transmission of influenza virus infection in mice. I. The period of transmissibility. J. exp. Med 118:257
    [Google Scholar]
  5. Schulman J. L. 1967; Experimental transmission of influenza virus infection in mice. III. Differing effects of immunity induced by infection and by inactivated influenza virus vaccine on transmission of infection. J. exp. Med 125:467
    [Google Scholar]
  6. Vilcek J. 1969; Virology Monographs, No. 6. Interferon pp. 106–11 New York: Springer-Verlag, New York, Inc;
    [Google Scholar]
  7. Youngner J. S. 1968 Interferon production in mice injected with viral and nonviral stimuli. In Medical and Applied Virology pp. 210–22 Ed. by Sanders M., Lennette E. H. St Louis, Mo: Warren H. Green, Inc;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-5-3-429
Loading
/content/journal/jgv/10.1099/0022-1317-5-3-429
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error