The growth of rubella virus in suspended BHK 21 cells was studied by electron microscopy under conditions of one-step growth. After a latent period of 15 hr the first new virus particles were found with their number increasing successively till about 25 hr. This corresponded well with the infectivity assays obtained from these samples.

The virus is formed through two pathways; first, by budding into vesicles of the Golgi-apparatus which then are emptied outside the cells; second, to a lesser extent by budding directly from the marginal cell membrane. No accumulation of nucleoids in the cytoplasm is detected, but they are formed at the site of budding.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error