RT Journal Article SR Electronic(1) A1 Blevins, R. Dean A1 Dumic, Michael P.YR 1980 T1 The Effect of Δ-9-Tetrahydrocannabinol on Herpes Simplex Virus Replication JF Journal of General Virology, VO 49 IS 2 SP 427 OP 431 DO https://doi.org/10.1099/0022-1317-49-2-427 PB Microbiology Society, SN 1465-2099, AB SUMMARY Both herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) failed, in an identical fashion to replicate and produce extensive c.p.e. in human cell monolayer cultures which were exposed (8 h before infection, at infection, or 8 h p.i.) to various concentrations of Δ-9-tetrahydrocannabinol. Similar results were obtained with a plaque assay utilizing confluent monkey cells. Possible mechanisms for this antiviral activity are discussed., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-49-2-427