RT Journal Article SR Electronic(1) A1 Jones, Charlotte L. A1 Holland, John J.YR 1980 T1 Requirements for DI Particle Prophylaxis Against Vesicular Stomatitis Virus Infection in vivo JF Journal of General Virology, VO 49 IS 1 SP 215 OP 220 DO https://doi.org/10.1099/0022-1317-49-1-215 PB Microbiology Society, SN 1465-2099, AB SUMMARY In contrast to biologically active DI particles, neither u.v.-inactivated standard virus nor either of two different homologous u.v.-inactivated DI particles showed any prophylactic effect when injected intracerebrally into mice concomitantly challenged with VSV. Although u.v.-inactivated DI particles did not prevent death when given with the challenge virus, they did significantly lengthen the time until death occurred. Also, both u.v.-inactivated standard virus and DI particles protected mice against late challenge (at 3 or 10 days after treatment). Dosage titrations of preparations of two different active DI particles showed significant prophylaxis against simultaneous challenge with numbers of DI particles 10- to 100-fold lower than those which gave no prophylaxis when u.v.-inactivated. Thus, prophylaxis in this system required biologically active DI particles., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-49-1-215