%0 Journal Article %A Toniolo, A. %A Matteucci, D. %A Pistillo, M. P. %A Gori, Z. %A Bendinelli, M. %T Early Replication of Friend Leukaemia Viruses in Spleen Macrophages %D 1980 %J Journal of General Virology, %V 49 %N 1 %P 203-208 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-49-1-203 %I Microbiology Society, %X SUMMARY The ability of spleen macrophages to support Friend leukaemia virus replication was studied by testing for infectivity in adherent cells obtained from mice at various times after infection. Virus-releasing macrophages appeared early after infection and reached a high proportion. The released virus was probably synthesized de novo since macrophage infectivity was strongly reduced by treatments which affected cellular viability or synthetic activities and electron microscopy showed C-type particles budding from macrophages. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-49-1-203