1887

Abstract

SUMMARY

By filtration of normal human serum through a Sephadex G-200 column, an anti-virus release factor (AVRF), which is capable of inhibiting the release of Epstein-Barr virus (EBV) from cells cultured , was found in the fractions corresponding to IgM. Another component, antagonistic to the activity of AVRF, was found in the fractions close to those of albumin. Both AVRF and anti-AVRF were found in all sera from four EBV seropositive and three seronegative adults tested. EBV-release inhibition by AVRF was reversible. AVRF did not neutralize virus infectivity or inhibit intracellular virus growth. Virus adsorption on to cells was not prevented by AVRF but cap formation of EBV antigens on cells was augmented by it.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-49-1-197
1980-07-01
2022-01-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/49/1/JV0490010197.html?itemId=/content/journal/jgv/10.1099/0022-1317-49-1-197&mimeType=html&fmt=ahah

References

  1. Allen R., Finkelstein R. A., Sulkin S. Z. 1958; Viral inhibitors in animal sera. Texas Reports on Biology and Medicine 16:392–421
    [Google Scholar]
  2. Couch R. B., Kasel J. A., Gerin J. L., Schulman J. L., Kilbourne E. D. 1974; Induction of partial immunity to influenza by a neuraminidase-specific vaccine. Journal of Infectious Diseases 129:411–420
    [Google Scholar]
  3. Hinuma Y., Suzuki M., Sairenji T. 1975; Epstein-Barr virus-induced cap formation in human lympho-blastoid cells. International Journal of Cancer 15:799–805
    [Google Scholar]
  4. Kilbourne E. D., Palese P., Schulman J. L. 1975; Inhibition of viral neuraminidase as a new approach to the prevention of influenza. In Antiviral Mechanisms, Perspective in Virology vol 9 pp 99–114 Edited by Pollard M. New York: Academic Press;
    [Google Scholar]
  5. Matsumoto M., Tada Y., Yamaguchi J., Sairenji T., Hinuma Y. 1980; Further studies on inhibition of Epstein-Barr virus release by bovine serum: partial purification and characterization of the inhibitor. Journal of the National Cancer Institute 64:353–357
    [Google Scholar]
  6. Murphy B. R., Kasel J. A., Chanock R. M. 1972; Association of serum anti-neuraminidase antibody with resistance to influenza in man. New England Journal of Medicine 286:1329–1332
    [Google Scholar]
  7. Sairenji T., Hinuma Y. 1973a; Modes of Epstein-Barr virus infection in human floating cell lines. Gann 64:583–590
    [Google Scholar]
  8. Sairenji T., Hinuma Y. 1973b; Assay of Epstein-Barr virus by immunofluorescence. Gann 64:633–636
    [Google Scholar]
  9. Sairenji T., Hinuma Y. 1975; Inhibitory effect of adult bovine serum on release of infectious Epstein-Barr virus from a virus-carrier cell line. Journal of the National Cancer Institute 55:339–343
    [Google Scholar]
  10. Sakamoto K. 1977; Search for infectious Epstein-Barr virus-releasing cell lines, with particular reference to new producer line, NHAd-60. Gann 68:145–150
    [Google Scholar]
  11. Schulman J. L., Khakpour M., Kilbourne E. D. 1968; Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice. Journal of Virology 2:778–786
    [Google Scholar]
  12. Seto J. T., Rott R. 1966; Functional significance of sialidase during influenza virus multiplication. Virology 30:731–737
    [Google Scholar]
  13. Wassermann F. E. 1968; Method for the study of viral inhibitors. In Methods in Virology vol 4 pp 53–92 Edited by Maramorosch K., Koprowski H. New York: Academic Press;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-49-1-197
Loading
/content/journal/jgv/10.1099/0022-1317-49-1-197
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error