@article{mbs:/content/journal/jgv/10.1099/0022-1317-48-2-451, author = "Darby, Graham and Larder, Brendan A. and Bastow, Kenneth F. and Field, Hugh J.", title = "Sensitivity of Viruses to Phosphorylated 9-(2-hydroxyethoxymethyl)Guanine Revealed in TK-transformed Cells", journal= "Journal of General Virology", year = "1980", volume = "48", number = "2", pages = "451-454", doi = "https://doi.org/10.1099/0022-1317-48-2-451", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-48-2-451", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY Vaccinia and pseudorabies viruses are resistant to ACV [Acyclovir or 9-(2-hydroxyethoxymethyl)guanine] in normal cells. However, both viruses are sensitive in thymidine kinase (TK)-transformed cells in which the resident HSV-specific TK is able to phosphorylate the drug. This demonstrates the sensitivity of these viruses to phosphorylated ACV and suggests a wider antiviral activity for the phosphorylated drug.", }