RT Journal Article SR Electronic(1) A1 Fuller, Frederick J. A1 Marcus, Philip I.YR 1980 T1 Interferon Induction by Viruses. Sindbis Virus: Defective-interfering Particles Temperature-sensitive for Interferon Induction JF Journal of General Virology, VO 48 IS 2 SP 391 OP 394 DO https://doi.org/10.1099/0022-1317-48-2-391 PB Microbiology Society, SN 1465-2099, AB SUMMARY A defective-interfering (DI) particle of Sindbis virus was generated from a ts mutant of RNA− complementation group A by serially undiluted passages at 30 °C. This mutant induced interferon at a permissive temperature (30 °C), but not at a non-permissive temperature (40.5 °C); it also expressed homotypic interference throughout the range 30 to 40.5 °C. This demonstrates for the first time in a DI particle a ts function, namely, the ability to induce interferon. In addition, our data provide further evidence that the RNA genome of a Sindbis DI particle can be translated within the cell. We postulate that the products of translation function to produce the putative inducer of interferon, namely a molecule of dsRNA., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-48-2-391