Lymph node cells, regional to the site of infection with herpes simplex virus type 1 (HSV-1), when taken 1 to 9 months p.i. and transferred to HSV-1 immune recipients, suppressed the delayed type hypersensitivity (DTH) reaction to the virus. The suppressive activity was specific for HSV-1 and was transferred by a thy-1.2-negative, Ig-positive, lymphocyte population. Anti-HSV-1 serum did not suppress the HSV-1-induced DTH response. Contralateral lymph nodes contained little or no suppressor cells activity but in infected, adult thymectomized mice, these lymph node cells were as effective as the draining node in transferring suppression. The significance of these observations for the pathogenesis of herpes infections is discussed.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error