1887

Abstract

Summary

Host-range variants of mouse mammary tumour viruses (MMTVs) have previously been shown to productively infect cells of several species (Howard & Schlom, 1978). We report here that cell lines have been identified which exhibit differential restriction for replication of different MMTV variants. In addition, a cell line has been identified that changes as a function of passage in culture from being permissive to being restrictive to infection with MMTVs. MMTVs propagated in both murine and non-murine cells retained their antigenic reactivities in a group-specific radioimmunoassay for MMTVs and demonstrated no evidence for the presence of type-C viruses as determined by a variety of techniques. These studies thus establish cell substrate tropisms that can be used to differentiate between MMTVs.

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/content/journal/jgv/10.1099/0022-1317-47-2-439
1980-04-01
2019-10-23
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-47-2-439
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