1887

Abstract

SUMMARY

Cultures of foetal lymphocytes were exposed to u.v.-irradiated herpes simplex virus (HSV). The cells responded with increased 6-H-thymidine incorporation, the formation of clumps of enlarged lymphoblastoid cells and cell division. This response was first detected 3 to 4 days after exposure to virus material and was shown to be virus-dose dependent. The ability to stimulate foetal cells was considerably more u.v. resistant than infectivity. Two isolates of HSV type 2 (4663 and 37174), which had a high ‘transforming’ ability, produced large numbers of non-infectious particles (particle: infectivity ratios in excess of 10). The cells, which responded to u.v.-irradiated HSV with blastoid transformation, were associated with the non-E-rosetting (T-cell-depleted) subpopulation.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-47-1-151
1980-03-01
2022-01-17
Loading full text...

Full text loading...

/deliver/fulltext/jgv/47/1/JV0470010151.html?itemId=/content/journal/jgv/10.1099/0022-1317-47-1-151&mimeType=html&fmt=ahah

References

  1. Bloom B. R. 1979; Games parasites play: how parasites evade immune surveillance (review). Nature, London 379:21–26
    [Google Scholar]
  2. Bouroncle B. A., Clausen K. P., Darner E. M. 1970; Replication of herpes simplex virus in cultures of phytohaemagglutinin stimulated human lymphocytes. Journal of the National Cancer Institute 44:1065–1078
    [Google Scholar]
  3. Dostal V., Retss-Gutfrund J., Binder M. 1977; The multiplication of herpes simplex virus type 2 (HSV-2) in isolated human lymphocytes. Oncology 34:198–200
    [Google Scholar]
  4. Falk L. A., Nigida S. M., Deindhardt F., Wolfe L. G., Cooper R. W., Hernandez-Camacho J. I. 1974; Herpes-virus ateles: properties of an oncogenic herpesvirus isolated from circulating lymphocytes of spider monkeys. International Journal of Cancer 14:473–482
    [Google Scholar]
  5. Hulliger L., Wilde J. K. H., Brown C. G. D., Turner L. 1964; Mode of multiplication of Theileria in cultures of bovine lymphocytic cells. Nature, London 203:728–730
    [Google Scholar]
  6. Kirchner H., Kleinicke C., Northoff H. 1977; Replication of herpes simplex virus in human peripheral T-lymphocytes. Journal of General Virology 37:647–649
    [Google Scholar]
  7. Klein G. 1973; The Epstein-Barr virus. In The Herpesviruses p 521 Edited by Kaplan A. S. New York: Academic Press;
    [Google Scholar]
  8. Lay W. H., Mendes N. F., Bianco C., Nussenzweig V. 1971; Binding of sheep red blood cells to a large population of human lymphocytes. Nature, London 230:531–532
    [Google Scholar]
  9. Lowry S. O., Rawls W. E., Melnick J. L. 1971; Investigation of plaque formation in chick embryo cells as a biological marker for distinguishing herpes type 2 from 1. Journal of General Virology 10:1–9
    [Google Scholar]
  10. Mochizuki D., Hedrick S., Watson J., Kingsbury D. T. 1977; The interaction of herpes simplex virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus. Journal of Experimental Medicine 146:1500–1510
    [Google Scholar]
  11. Payne L. N., Powell P. C., Rennie M. 1974; Response of B and T lymphocytes and other blood leukocytes in chickens with Marek’s Disease. Cold Spring Harbor Symposia on Quantitative Biology 39:817–826
    [Google Scholar]
  12. Pelton B. K., Imrie C., Denman A. M. 1977; Susceptibility of human lymphocyte populations to infection by herpes simplex virus. Immunology 32:803–810
    [Google Scholar]
  13. Plummer G., Warner J. L., Phuangsab A., Goodheart G. R. 1970; Type 1 and type 2 herpes simplex viruses: serological and biological differences. Journal of Virology 5:51–59
    [Google Scholar]
  14. Ross L. J. N., Wildy P., Cameron K. R. 1971; Formation of small plaques by herpes virus irradiated with ultra-violet light. Virology 45:808–812
    [Google Scholar]
  15. Westmoreland D. 1978; Herpes simplex virus Type 1 and human lymphocytes: virus expression and the response to infection of adult and foetal cells. Journal of General Virology 40:559–575
    [Google Scholar]
  16. Westmoreland D., Rapp F. 1976; Host range temperature sensitive mutants of herpes simplex virus type 1. Journal of Virology 18:92–102
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-47-1-151
Loading
/content/journal/jgv/10.1099/0022-1317-47-1-151
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error