1887

Abstract

SUMMARY

In transformed mouse embryo cells, type II interferon had much less antiviral activity than type I interferon. In non-transformed cells, the two interferons had similar high activity. Reversal of the phenotype of Moloney sarcoma virus (MSV) transformed cells by sodium butyrate restored their sensitivity to the antiviral action of type II interferon. Additional evidence for a role of the cytoskeletal network in the action of type II interferon is that its antiviral effect is reduced by cytochalasin B, colchicine or vinblastine. MSV-transformed cells, selected for their resistance to the antiviral action of type I interferon, were sensitive to type II interferon. These differences in the effects of type I and II interferon on transformed cells are at present unexplained, but suggest that they have at least partially separate mechanisms of action.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-46-2-449
1980-02-01
2022-10-01
Loading full text...

Full text loading...

/deliver/fulltext/jgv/46/2/JV0460020449.html?itemId=/content/journal/jgv/10.1099/0022-1317-46-2-449&mimeType=html&fmt=ahah

References

  1. Aitenburg B. C., Via D. P., Steiner S. H. 1976; Modification of the phenotype of murine sarcoma virus transformed cells by sodium butyrate. Experimental Cell Research 102:223–231
    [Google Scholar]
  2. Baron S., Dianzani F. (Editors) 1977 In The Interferon System: a Current Review to 1978. Texas Reports on Biology and Medicine 35 Galveston: University of Texas Medical Branch;
    [Google Scholar]
  3. Bourgeade M. F. 1978; Effet du butyrate de sodium sur la sensibility h l’interf6ron de cellules normales et transformees par le virus du sarcome murin. Comptes Rendus hebdomadaires des Seances de VAcademie des Sciences serie D 287:391–394
    [Google Scholar]
  4. Bourgeade M. F., Chany C. 1976; Inhibition of interferon action by cytochalasin B, colchicine, and vinblastine. Proceedings of the Society for Experimental Biology and Medicine 153:501–504
    [Google Scholar]
  5. Brailovsky C., Berman L. D., Chany C. 1969; Decreased interferon sensitivity and production in cells transformed by SV 40 and other oncogenic agents. International Journal of Cancer 4:194–203
    [Google Scholar]
  6. Brinkley B. R., Fuller G. M., Highfield D. P. 1975; Cytoplasmic microtubules in normal and transformed cells in culture: analysis by tubulin antibody immunofluorescence. Proceedings of the National Academy of Sciences of the United States of America 72:4981–4985
    [Google Scholar]
  7. Chany C., Vignal M. 1970; Effect of prolonged interferon treatment on mouse embryonic fibroblasts transformed by murine sarcoma virus. Journal of General Virology 7:203–210
    [Google Scholar]
  8. Dianzani F., Slater L., Fleischmann W. R. Jun, Zucca M. 1978; Immune interferon activates cells more slowly than does virus-induced interferon. Proceedings of the Society for Experimental Biology and Medicine 159:94–97
    [Google Scholar]
  9. Epstein L. B., Epstein D. J. 1976; Localization of the gene AVG for the antiviral expression of immune and classical interferon to the distal portion of the long arm of chromosome 21. Journal of Infectious Diseases 133:A56–A62
    [Google Scholar]
  10. Pollack R., Osborn M., Weber K. 1975; Pattern organization of actin and myosin in normal and transformed cultured cells. Proceedings of the National Academy of Sciences of the United States of America 72:994–998
    [Google Scholar]
  11. Salvin S. B., Youngner J. S., Nishio J., Heta R. 1975; Tumor suppression by a lymphokine released into the circulation of mice with delayed hypersensitivity. Journal of the National Cancer Institute 55:1233–1238
    [Google Scholar]
  12. Sonnenfeld G., Mandel A. D., Merigan T. C. 1978; Immunoenhancement by murine type II interferon preparation. Cellular Immunology 40:285–293
    [Google Scholar]
  13. Sonnenfeld G., Meruelo D., Mcdevitt H. O., Merigan T. C. 1979; Effect of interferon on murine lymphocyte surface antigen expression. I. Studies with type II interferon. Submitted for publication
    [Google Scholar]
  14. Wietzerbin J., Stephanos S., Falcoff R., Falcoff E. 1977; Some properties of interferon induced by stimulants of T and B lymphocytes. In The Interferon System: a Current Review to 1978, Texas Reports on Biology and Medicine 35205–211 Edited by Baron S., Dianzani F. Galveston: University of Texas Medical Branch;
    [Google Scholar]
  15. Youngner J. S., Salvin S. B. 1973; Production and properties of migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity. Journal of Immunology 111:1914–1922
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-46-2-449
Loading
/content/journal/jgv/10.1099/0022-1317-46-2-449
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error