1887

Abstract

SUMMARY

The antiviral responses in mice to intranasal inoculation with Sendai virus are described. To investigate the relative importance of the humoral, cell-mediated and interferon responses, the pathogenesis of this infection was studied in animals which were immunocompetent, T cell-deprived or immunosuppressed with cyclophosphamide. Treatment with cyclophosphamide converted the mild, self-limiting infection observed in immunocompetent mice into a severe and frequently lethal pneumonic disease. This was associated with an enhanced interferon response but not detectable antibody or cell-mediated immune response. T cell-deprived mice suffer an infection of intermediate severity associated with an increased interferon response, a normal humoral immune response and no cell-mediated immune response. The implications of these results in relation to the role of the antiviral responses in recovery from Sendai virus infection are discussed.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-46-2-373
1980-02-01
2024-12-07
Loading full text...

Full text loading...

/deliver/fulltext/jgv/46/2/JV0460020373.html?itemId=/content/journal/jgv/10.1099/0022-1317-46-2-373&mimeType=html&fmt=ahah

References

  1. Anderson M. J. 1978; Innate cytoxicity of CBA mouse spleen cells to Sendai virus-infected L cells. Infection and Immunity 20:608–612
    [Google Scholar]
  2. Anderson M. J., Bainbridge D. R., Pattison J. R., Heath R. B. 1977; Cell-mediated immunity to Sendai virus infection in mice. Infection and Immunity 15:239–244
    [Google Scholar]
  3. Anderson M. J., Pattison J. R., Heath R. B. 1979; The nature of the effector cells of cell-mediated immune responses to Sendai and Kunz virus infections in mice. British Journal of Experimental Pathology 60:314–319
    [Google Scholar]
  4. Blandford G. 1975; Studies on the immune response and pathogenesis of Sendai virus infection of mice. HI. The effects of cyclophosphamide. Immunology 28:1–13
    [Google Scholar]
  5. Blandford G., Cureton R. J. R., Heath R. B. 1971; Studies of the immune response in Sendai virus infection of mice. Journal of Medical Microbiology 4:351–356
    [Google Scholar]
  6. Blandford G., Heath R. B. 1974; Studies on the immune response and pathogenesis of Sendai virus infection of mice. II. The immunoglobulin class of plasma cells in the bronchial submucosa. Immunology 26:667–671
    [Google Scholar]
  7. Burns W. H., Allison A. C. 1975 In The Antigens vol 3 chapter 7 pp 480–559 Edited by Sela M. New York: Academic Press;
  8. Horsfall F. L. 1939; Neutralisation of epidemic influenza virus. The linear relationship between the quantity of serum and the quantity of virus neutralised. Journal of Experimental Medicine 70:209–222
    [Google Scholar]
  9. Iwasaki I., Nozima T. 1977; Defence mechanisms against primary influenza virus infection in mice. I. The roles of interferon and neutralising antibodies and thymus dependence of interferon and antibody production. Journal of Immunology 118:256–263
    [Google Scholar]
  10. Jennings R., Fenton R. J., Mcentegart M. G., Potter C. W. 1978; A contribution of cellular immunity to protection against influenza in man. Medical Microbiology and Immunology 166:51–62
    [Google Scholar]
  11. Reed L. R., Muench H. 1938; A simple method of estimating fifty per cent end points. American Journal of Hygiene 27:493–497
    [Google Scholar]
  12. Robinson T. W. E., Cureton R. J. R., Heath R. B. 1968; The pathogenesis of Sendai virus infection in the mouse lung. Journal of Medical Microbiology 1:89–95
    [Google Scholar]
  13. Robinson T. W. E., Cureton R. J. R., Heath R. B. 1969; The effect of cyclophosphamide on Sendai virus infection of mice. Journal of Medical Microbiology 2:137–145
    [Google Scholar]
  14. Virelizier J. L., Postlethwaite R., Schild G. C., Allison A. C. 1974; Antibody responses to antigenic determinants of influenza virus haemagglutinin. I. Thymus dependence of antibody formation and thymus independence of immunological memory. Journal of Experimental Medicine 140:1559–1570
    [Google Scholar]
  15. Yap K. L., Ada G. L. 1978; Cytotoxic T cells in the lungs of mice infected with an influenza virus. Scandinavian Journal of Immunology 7:73–80
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-46-2-373
Loading
/content/journal/jgv/10.1099/0022-1317-46-2-373
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error