1887

Abstract

SUMMARY

Ultraviolet-irradiated herpes simplex virus (u.v.-HSV) induced endogenous xenotropic type C virus from A1–2 cells, derived from the BALB/c mouse, as determined by infectious centre focus-forming assay on permissive normal rat kidney (NRK) cells. The number of cells induced to release type C virus by irradiated HSV was dependent on the level of u.v. exposure received by the HSV. Optimal induction occurred when cells were infected with irradiated HSV during their exponential growth phase. Virus induction decreased under conditions of simultaneous cellular exposure to hydroxyurea or actinomycin D, inhibitors of DNA and RNA synthesis, respectively, with actinomycin D having a greater inhibitory effect. This suggests that both DNA and RNA synthesis are required for irradiated HSV induction of murine xenotropic virus. Hydroxyurea decreased induction in the first few hours after infection of A1–2 cells with irradiated HSV, suggesting that the biological events involving DNA synthesis which are required for induction by u.v.-HSV occur shortly after infection.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-46-2-267
1980-02-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/46/2/JV0460020267.html?itemId=/content/journal/jgv/10.1099/0022-1317-46-2-267&mimeType=html&fmt=ahah

References

  1. Aaronson S. A. 1971; Chemical induction of focus forming virus from nonproducer cells transformed by murine sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America 68:3069–3072
    [Google Scholar]
  2. Aaronson S. A., Todaro G. J., Scolnick E. M. 1971; Induction of murine C-type viruses from clonal lines of virus-free BALB/3T3 cells. Science 174:157–159
    [Google Scholar]
  3. Duc-Nguyen H., Rosenblum E. N., Zeigel R. F. 1966; Persistent infection of a rat kidney cell line with Rauscher murine leukemia virus. Journal of Bacteriology 92:1133–1140
    [Google Scholar]
  4. Duff R., Rapp F. 1975; Quantitative assay for transformation of 3T3 cells by herpes simplex virus type 2. Journal of Virology 15:490–496
    [Google Scholar]
  5. Flugel R. M., Darai G., Braun R., Munk K. 1977; Activation of an endogenous C-type RNA virus in rat embryo cells after transformation by herpes simplex virus type i and 2. Journal of General Virology 36:365–369
    [Google Scholar]
  6. Gazdar A. F., Chopra H. C., Sarma P. S. 1972; Properties of a murine sarcoma virus isolated from a tumor arising in an NZW/NZB Fx hybrid mouse. I. Isolation and pathology of tumors induced in rodents. International Journal of Cancer 9:219–233
    [Google Scholar]
  7. Gazdar A. F., Russell E. K., Minna J. D. 1974; Replication of mouse-tropic and xenotrophic strains of murine leukemia virus in human × mouse hybrid cells. Proceedings of the National Academy of Sciences of the United States of America 71:2642–2645
    [Google Scholar]
  8. Greenberger J. S., Aaronson S. A. 1975; Cycloheximide induction of xenotropic type C virus from synchronized mouse cells: metabolic requirements for virus activation. Journal of Virology 15:64–70
    [Google Scholar]
  9. Greenberger J. S., Phillips S. M., Stephenson J. R., Aaronson S. A. 1975; Induction of mouse type-C RNA virus by lipopolysaccharide. Journal of Immunology 115:317–320
    [Google Scholar]
  10. Hampar B., Aaronson S. A., Derge J. G., Chakrabarty M., Show Alter S. D., Dunn C. Y. 1976; Activation of an endogenous mouse type C virus by ultraviolet-irradiated herpes simplex virus types1and 2. Proceedings of the National Academy of Sciences of the United States of America 73:646–650
    [Google Scholar]
  11. Hampar B., Hatanaka M., Aulakh G., Derge J. G., Lee L., Showalter S. 1977; Type C virus activation in ‘nontransformed’ mouse cells by UV-irradiated herpes simplex virus. Virology 76:876–881
    [Google Scholar]
  12. Hellman A., Fowler A. K. 1971; Hormone-activated expression of the C-type RNA tumor virus genome. Nature New Biology 233:142–144
    [Google Scholar]
  13. Hellman K. B., Brewer P. P. 1979; Ultraviolet radiation induction of endogenous murine type C virus. Mutation Research 62:205–212
    [Google Scholar]
  14. Hirsch M. S., Black P. H. 1974; Activation of mammalian leukemia viruses. Advances in Virus Research 19:265–313
    [Google Scholar]
  15. Huebner R. J., Kelloff G. J., Sarma P. S., Lane W. T., Turner H. C., Gilden R. V., Oroszlan S., Meier H., Myers D. D., Peters R. L. 1970; Group-specific antigen expression during embryogenesis of the genome of the C-type RNA tumor virus: implications for ontogenesis and oncogenesis. Proceedings of the National Academy of Sciences of the United States of America 67:366–376
    [Google Scholar]
  16. Jacobson E. D., Krell K., Dempsey M. J., Lugo M. H., Ellingson O., Hench C. W. II 1978; Toxicity and mutagenicity of radiation from fluorescent lamps and a sunlamp in L5178Y mouse lymphoma cells. Mutation Research 51:61–75
    [Google Scholar]
  17. Jainchill J. L., Aaronson S. A., Todaro G. J. 1969; Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells. Journal of Virology 4:549–553
    [Google Scholar]
  18. Kufe D., Hehlmann R., Spiegelman S. 1973; RNA related to that of a murine leukemia virus in Burkitt’s tumors and nasopharyngeal carcinomas. Proceedings of the National Academy of Sciences of the United States of America 70:5–9
    [Google Scholar]
  19. Lowy D. R., Rowe W. P., Teich N., Hartley J. W. 1971; Murine leukemia virus: high-frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine. Science 174:155–156
    [Google Scholar]
  20. Lytle C. D. 1971; Host cell reactivation in mammalian cells, I. Survival of ultraviolet-irradiated herpes virus in different cell lines. International Journal of Radiation Biology 19:329–337
    [Google Scholar]
  21. Moroni C., Schumann G. 1975; Lipopolysaccharide induces C-type virus in short term cultures of BALB/c spleen cells. Nature, London 254:60–61
    [Google Scholar]
  22. Osato T., Mizuno F., Yamamoto K., Nonoyama M. 1975; Alteration in Epstein-Barr virus-human lymphoid cell interactions caused by the presence of type-C viral genome. In Oncogenesis and Herpesviruses vol II pp 27–35 Edited by de-The G., Epstein M. A., Zur Hausen H. Lyon: IARC;
    [Google Scholar]
  23. Otten J. A., Quarles J. M., Tennant R. W. 1976; Cell division requirement for activation of murine leukemia virus in cell culture by irradiation. Virology 70:80–87
    [Google Scholar]
  24. Peters P., Kufe D., Schlom J., Frankel J. W., Prickett C. O., Groupe V., Spiegelman S. 1973; Biological and biochemical evidence for an interaction between Marek’s disease herpes-virus and avian leukosis virus in vivo. Proceedings of the National Academy of Sciences of the United States of America 70:3175–3178
    [Google Scholar]
  25. Rascati R. J., Tennant R. W. 1978; Induction of endogenous murine retrovirus by hydroxyurea and related compounds. Virology 87:208–211
    [Google Scholar]
  26. Reed C. L., Rapp F. 1976; Induction of murine P30 by superinfecting herpesviruses. Journal of Virology 19:1028–1033
    [Google Scholar]
  27. Robb J. A., Martin R. G. 1972; Genetic analysis of simian virus 40. 3. Characterization of a temperature-sensitive mutant blocked at an early stage of productive infection in monkey cells. Journal of Virology 9:956–958
    [Google Scholar]
  28. Rowe W. P., Hartley J. W., Lander M. R., Pugh W. E., Teich N. 1971; Non-infectious AKR mouse embryo cell lines in which each cell has the capacity to be activated to produce infectious murine leukemia virus. Virology 46:866–876
    [Google Scholar]
  29. Teich N., Lowy D. R., Hartley J. W., Rowe W. P. 1973; Studies of the mechanism of induction of infectious murine leukemia virus from AKR mouse embryo cell lines by 5-iododeoxyuridine and 5-bromodeoxyuridine. Virology 51:163–173
    [Google Scholar]
  30. Toyoshima K., Vogt P. K. 1969; Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions. Virology 38:414–426
    [Google Scholar]
  31. Yang S. S., Ablashi D., Armstrong G., Ting R. C. 1974; RNA-dependent DNA polymerase associated with a simian lymphoid cell line derived from a Herpesvirus saimiri-induced lymphoma. International Journal of Cancer 13:82–90
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-46-2-267
Loading
/content/journal/jgv/10.1099/0022-1317-46-2-267
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error