%0 Journal Article %A Kurimura, Takashi %A Hirano, Akiko %T DNA Synthesis and Multinucleation of Mouse Cells Infected with SV40 in the Presence of Cytochalasin B %D 1980 %J Journal of General Virology, %V 46 %N 1 %P 237-242 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-46-1-237 %I Microbiology Society, %X SUMMARY DNA synthesis and nuclear division of mouse cells, BALB/3T3, infected with SV40 were studied and were compared with those of SV40-transformed mouse cells, mKS-A TU-7. Both SV40-infected and SV40-transformed cells behaved similarly in the presence of cytochalasin B and differently from normal non-infected cells, BALB/3T3. The chemical inhibited cytokinesis of all the cell groups but the nuclear division was inhibited only in the case of non-infected BALB/3T3. With SV40-infected BALB/3T3, multinucleation occurred with the increase of input m.o.i. by SV40. SV40-infected BALB/3T3 could enter the second S phase after release from double thymidine block in the presence of cytochalasin B, while BALB/3T3 could not enter the second S phase. In bi- or multinucleated cells of SV40-infected BALB/3T3, asynchrony of DNA synthesis among nuclei in a cell was evident, as was the case with mKS-A TU-7. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-46-1-237