1887

Abstract

SUMMARY

The effects of low doses (40 to 1000 units/ml) of mouse interferon (IF) on the expression of Friend leukaemia virus (FLV) and globin genes in Friend leukaemia cells (FLC) have been examined. IF blocks production of extracellular virus, but virus antigens accumulate in the cytoplasm. In cells treated with IF at the time of seeding, there is a reduction in the amount of RNA specified by the lymphatic leukaemia virus (LLV) component of FLV; with the same IF dose there is a small but definite stimulation of haemoglobin and globin mRNA synthesis. The effects of IF on LLV gene expression are even more pronounced in dimethyl sulphoxide (DMSO)-stimulated FLC. No correlation was found between LLV gene expression and the appearance of erythroid markers.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-46-1-227
1980-01-01
2021-10-27
Loading full text...

Full text loading...

/deliver/fulltext/jgv/46/1/JV0460010227.html?itemId=/content/journal/jgv/10.1099/0022-1317-46-1-227&mimeType=html&fmt=ahah

References

  1. Amici D., Rossi G. B., Cioè L., Matarese G. P., Dolei A., Guglielmi L., Gianfranceschi G. L. 1977; Low-molecular-weight peptide inhibits RNA synthesis in human leukemic and phytohemagglutinin-stimulated leukocytes and globin mRNA transcription in differentiating Friend cells. Proceedings of the National Academy of Sciences of the United States of America 74:3869–3873
    [Google Scholar]
  2. Bastos R. N., Volloch Z., Aviv H. 1977; Messenger RNA population analysis during erythroid differentiation: a kinetical approach. Journal of Molecular Biology 110:191–203
    [Google Scholar]
  3. Billiau A., Heremans H., Allen P. T., De Maeyer-Guignard J., De Somer P. 1976; Trapping of OnCOma-virus particles at the surface of interferon-treated cells. Virology 73:537–542
    [Google Scholar]
  4. Brown G. E., Lebleu B., Kawakita M., Shaila S., Sen G. C., Lengyel P. 1976; Increased endonuclease activity in an extract from mouse Erlich ascites tumor cells which had been treated with a partially purified interferon preparation: dependence on double-stranded RNA. Biochemical and Biophysical Research Communications 69:114–122
    [Google Scholar]
  5. Chang E. H., Friedman R. M. 1977; A large glycoprotein of Moloney leukemia virus derived from interferon-treated cells. Biochemical and Biophysical Research Communications 77:392–398
    [Google Scholar]
  6. Cioè L., Dolei A., Rossi G. B., Belardelli F., Affabris E., Gambari R., Fantoni A. 1978; Potential for differentiation, virus production and tumorigenicity in murine erythroleukemic cells treated with interferon. In In vitro Aspects of Erythropoiesis pp 159–171 Edited by Murphy M. J. New York: Springer-Verlag;
    [Google Scholar]
  7. Colletta G., Fragomele F., Sandomenico M. L., Vecchio G. 1979; Enhanced expression of viral polypeptides and messenger RNA in dimethyl sulfoxide- and bromodeoxyuridine-treated Friend erythroleukemic cells. Experimental Cell Research 119:253–264
    [Google Scholar]
  8. De Maeyer-Guignard J., Tovey M. G., Gresser I. 1978; Purification of mouse interferon by sequential affinity chromatography on poly(U)- and antibody-agarose columns. Nature, London 271:622–625
    [Google Scholar]
  9. Dolei A., Capobianchi M. R., Cioè L., Colletta G., Vecchio G., Rossi G. B., Affabris E., Belardelli F. 1978; Effects of interferon on the expression of cellular and integrated viral genes in Friend erythroleukemic cells. In Antiviral Mechanisms in the Control of Neoplasia pp 729–739 Edited by Chandra P. New York: Plenum Press;
    [Google Scholar]
  10. East J. L., Knesek J. E., Chan J. C., Dmochowski L. 1975; Quantitative nucleotide sequence relationships of mammalian RNA tumor viruses. Journal of Virology 15:1396–1408
    [Google Scholar]
  11. Fan H., Macisaac P. 1978; Virus-spedific RNA synthesis in interferon-treated mouse cells productively infected with Moloney murine leukemia virus. Journal of Virology 27:449–452
    [Google Scholar]
  12. Friedman R. M. 1977; Antiviral activity of Interferons. Bacteriological Review 41:543–567
    [Google Scholar]
  13. Friend C. 1978; The phenomenon of differentiation in murine erythroleukemic cells. Harvey Lectures Series 72:253–281
    [Google Scholar]
  14. Friend C., Scher W., Tsuei D., Haddad J., Holland J. C., Szrajer N., Haubenstock H. 1979 In Oncogenic viruses and Host Genes pp 279–301 Edited by Ikawa Y. New York: Academic Press;
    [Google Scholar]
  15. Harrison P. R. 1977; The biology of Friend cells. In Biochemistry of Cell Differentiation, MTP International Review of Science series II pp 227–267 Edited by Paul J. London: University Park Press;
    [Google Scholar]
  16. Kerr L. M., Brown R. E., Clemens M. J., Gilbert C. S. 1976; Interferon-mediated inhibition of cell-free protein synthesis in response to double-stranded RNA. European Journal of Biochemistry 69:551–561
    [Google Scholar]
  17. Krieg C. J., Ostertag W., Klauss U., Pragnell J. B., Swetly P., Roesler G., Weiman B. J. 1978; Increase in intracisternal A-type particles in Friend cells during inhibition of Friend virus (SFFV) release by interferon or azidothymidine. Experimental Cell Research 116:21–29
    [Google Scholar]
  18. Lieberman D., Volloch Z., Aviv H., Nudel V., Revel M. 1975; Effects of interferon on hemoglobin synthesis and leukemia virus production in Friend cells. Molecular Biology Reports 1:447–451
    [Google Scholar]
  19. Luftig R. B., Conscience J. F., Skoultchi A., Mcmillan P., Revel M., Ruddle F. H. 1977; Effect of interferon on dimethyl sulfoxide-stimulated Friend erythroleukemic cells: ultrastructural and biochemical study. Journal of Virology 23:799–810
    [Google Scholar]
  20. Orkin S. H., Harosi F. I., Leder P. 1975; Differentiation in erythroleukemic cells and their somatic hybrids. Proceedings of the National Academy of Sciences of the United States of America 72:98–102
    [Google Scholar]
  21. Penman S. 1969; Preparation of purified nuclei and nucleoli from mammalian cells. In Fundamental Techniques in Virology pp 35–48 Edited by Habel K., Salzman N. P. New York: Academic Press;
    [Google Scholar]
  22. Pitha P. M., Rowe W. P., Oxman M. N. 1976; Effect of interferon on exogenous, endogenous and chronic murine leukemia virus infection. Virology 70:324–338
    [Google Scholar]
  23. Pragnell J., Ostertag W., Paul J. 1977; Expression of viral and globin genes during Friend cell differentiation. Experimental Cell Research 108:269–278
    [Google Scholar]
  24. Pragnell I. B., Mcnab A., Harrison P. R. 1978; Are spleen focus-forming virus sequences related to xeno-tropic viruses and expressed specifically in normal erythroid cells?. Nature, London 272:456–458
    [Google Scholar]
  25. Ramoni C., Rossi G. B., Matarese G. P., Dolei A. 1977; Production of Friend leukaemia virus antigens in chronically-infected cells treated with interferon. Journal of General Virology 37:285–296
    [Google Scholar]
  26. Ringold G., Lasfargues E. J., Bishop J. M., Varmus H. 1975; Production of mouse mammary tumour virus by cultured cells in the absence and presence of hormones: assay by molecular hybridization. Virology 65:135–147
    [Google Scholar]
  27. Rossi G. B., Dolei A., Cioè L., Benedetto A., Matarese G. P., Belardelli F. 1977; Inhibition of transcription and translation of globin messenger RNA in dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated with interferon. Proceedings of the National Academy of Sciences of the United States of America 74:2036–2040
    [Google Scholar]
  28. Salzberg S., Bakhanashvili M., Aboud M. 1978; Effect of interferon on mouse cells chronically infected with murine leukemia virus: kinetic studies on virus production and virus RNA synthesis. Journal of General Virology 40:121–130
    [Google Scholar]
  29. Sherton C. C., Evans L. H., Polonoff H., Kabat D. 1976; Relationship of Friend murine leukemia virus production to growth and hemoglobin synthesis in cultured erythroleukemia cells. Journal of Virology 19:118–125
    [Google Scholar]
  30. Sherton C. C., Kabat D. 1976; Changes in RNA and protein metabolism preceding onset of hemoglobin synthesis in cultured Friend Leukemia Cells. Developmental Biology 48:118–131
    [Google Scholar]
  31. Steeves R. A. 1975; Spleen focus-forming virus in Friend and Rauscher leukemia virus preparations. Journal of the National Cancer Institute 54:289–294
    [Google Scholar]
  32. Swetly P., Ostertag W. 1974; Friend virus release and induction of hemoglobin synthesis in erythroleukemia cells respond differently to Interferon. Nature, London 251:642–644
    [Google Scholar]
  33. Tovey G. M., Begon-Lourse J., Gresser I. 1974; A method for the large scale production of potent interferon preparations. Proceedings of the Society of Experimental Biology and Medicine 146:809–815
    [Google Scholar]
  34. Troxler D. H., Scolnicr E. M. 1978; Rapid leukemia induced by cloned Friend strain of replicating murine type-C virus. Association with induction of xenotropic-related RNA sequences contained in spleen focus-forming virus. Virology 85:17–27
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-46-1-227
Loading
/content/journal/jgv/10.1099/0022-1317-46-1-227
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error