1887

Abstract

SUMMARY

Mount Elgon bat virus given intracerebrally readily killed mice up to 12 days of age (1 to 4 p.f.u./LD). Virus in doses of 10 to 10 p.f.u. killed 40 to 80% of weanling mice of both sexes and up to 20% of adult females and 40 to 80% of adult males. Clearance of brain infectivity in the resistant mice coincided with the appearance of circulating virus neutralizing antibody which occurred earliest in the adult female mice. Immunosuppression of adult mice with cyclophosphamide resulted in the death of all the virus-inoculated mice of both sexes. Virus in these mice reached tenfold higher titres and their brains contained 30- to 60-fold more interferon than the brains of infected mice not given cyclophosphamide. Interferon was apparently without effect on the outcome of infection in the brains of resistant mice and its synthesis reflected the extent of virus growth.

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1979-12-01
2022-01-18
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References

  1. Albrecht P. 1968; Pathogenesis of neurotropic arbovirus infections. Current Topics in Microbiology and Immunology 43:44–91
    [Google Scholar]
  2. Cole O. A., Wisseman C. L. Jun 1969; Pathogenesis of type 1 dengue virus infection in suckling, weanling and adult mice. 1. The relation of virus replication to interferon and antibody formation. American Journal of Epidemiology 89:669–680
    [Google Scholar]
  3. Oougherty R. M. 1964 In Techniques in Experimental Virology pp 169–223 Edited by Harris R. C. London, New York: Academic Press;
    [Google Scholar]
  4. Gifford G. E. 1963; Studies on the specificity of interferon. Estimation of mouse interferon. Journal of General Microbiology 33:437–443
    [Google Scholar]
  5. Griffin D. E., Mullinix J., Narayan O., Johnson R. T. 1974; Age dependence of viral expression. Comparative pathogenesis of two rodent adapted strains of measles virus in mice. Infection and Immunity 9:690–695
    [Google Scholar]
  6. Heineberg H., Gold E., Robbins F. C. 1964; Differences in interferon content in tissues of mice of various ages infected with Coxsacki Bi virus. Proceedings of the Society for Experimental Biology and Medicine 115:947–953
    [Google Scholar]
  7. Huang C. H., Wong C. 1963; Relation of the peripheral multiplication of Japanese B encephalitis virus to the pathogenesis of the infection in mice. Acta Virologica 7:322–330
    [Google Scholar]
  8. Isaacs A., Baron S. 1960; Antiviral action of interferon in embryonic cells. Lancet ii:946–947
    [Google Scholar]
  9. Johnson R. T. 1964; The pathogenesis of herpes virus encephalitis. II. A cellular basis for the development of resistance with age. Journal of Experimental Medicine 120:359–374
    [Google Scholar]
  10. Johnson K. P., Johnson R. T. 1968; California encephalitis. II. Studies of experimental infection in the mouse. Journal of Neuropathology and Experimental Neurology 27:390–400
    [Google Scholar]
  11. Kunin C. M. 1962; Virus tissue union and the pathogenesis of enterovirus infections. Journal of immunology 88:556–569
    [Google Scholar]
  12. Metselaar D., Williams M. C., Simpson D. I. H., West R., Mutere R. A. 1969; Mount ElgOn bat virus, a hitherto undescribed virus from Rhinolophus hildebrandtii eloquens K. Anderson. Archiv fur die gesamte Virusforschung 26:183–193
    [Google Scholar]
  13. Mims C. A. 1964; Aspects of the pathogenesis of virus diseases. Bacteriological Reviews 28:30–71
    [Google Scholar]
  14. Murphy F. A., Shope R. E., Metselaar D., Simpson D. I. H. 1970; Characterization of Mount Elgon bat virus, a new member of the Rhabdovirus group. Virology 40:288–297
    [Google Scholar]
  15. Nathanson N., Cole G. A. 1970; Immunosuppression and experimental virus infection of the nervous system. In Advances in Virus Research 16 pp 397–438 Edited by Smith M. K. Lauffer M. A. Bang F. B. London, New York: Academic Press;
    [Google Scholar]
  16. Nathanson N., Cole G. A. 1971; Immunosuppression. A means to assess the role of the immune response in acute virus infections. Federation Proceedings 30:1822–1830
    [Google Scholar]
  17. Olson L. C., Sithisarn P., Djinawi N. K. 1975; Role of macrophages in Wesselsbron and Germiston virus infections of mice. Journal of Infectious Diseases 131:119–128
    [Google Scholar]
  18. Patel J. R. 1978; A plaque assay for Mount Elgon bat virus based on intrinsic interference. Journal of General Virology 40:659–664
    [Google Scholar]
  19. Patel J. R. 1979; Invasion of mouse brain by Mount Elgon bat virus. Journal of General Virology 44:587–597
    [Google Scholar]
  20. Thind I. S., Price W. H. 1969a; Cross protection with group B arboviruses in mice treated with cyclophosphamide. Role serum antibody, viraemia, and virus multiplication in the brain. American Journal of Epidemiology 89:89–97
    [Google Scholar]
  21. Thind I. S., Price W. H. 1969b; The effect of cyclophosphamide treatment on experimental arbovirus infections. American Journal of Epidemiology 90:62–68
    [Google Scholar]
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