When an avian sarcoma virus (ASV), subgroup C Bratislava 77 (B77-C) was inoculated into duck embryo fibroblast cultures (DEF) at a m.o.i. of 0.02, its replication was retarded by about 3 days compared with that in chick embryo fibroblast cultures (CEF). A transformation-defective (td) mutant was isolated during this period of retardation. Unlike the sarcoma virus, this td mutant replicated in both DEF and CEF with no retardation, even at a low m.o.i. The subgroup C Prague strain of Rous sarcoma virus (PR-C), which can infect DEF, also replicated in DEF slower than its td mutant, tdPR-C, at a m.o.i. of 0.02.
AndoT.,
TovoshimaK.1976; Genetic control of chick helper factor in cells which lack natural group specific antigens of avian leukosis. Virology 73:521–527
FujitaD. J.,
ChenY. C.,
FriisR. R.,
VogtP. K.1974; RNA tumor viruses of pheasants: characterization of avian leukosis subgroup F and G. Virology 60:558–571
NeimanP. E.,
Mcmillin-HelselC.,
CooperG. M.1978; Specific restriction of avian sarcoma viruses by a line of transformed lymphoid cells. Virology 89:360–371
PopovicM.,
SvobodaJ.,
SuniJ.,
VaheriA.,
PontenJ.1977; Expression of viral protein P27 in avian sarcoma virus-transformed mammalian cells and helper-dependent rescue of Rous sarcoma virus. International Journal of Cancer 19:834–842
StavnezerE.,
RingoldG.,
VarmusH. E.,
BishopJ. M.1976; RNA complementary to the genome of RNA tumor viruses in virions and virus producing cells. Journal of Virology 20:342–347
StoneM. P.,
SmithR. E.,
JoklikW. K.1975; 35S a and b RNA subunits of avian RNA tumor virus strains cloned and passaged in chick and duck cells. Cold Spring Harbor Symposia on Quantitative Biology 34:859–868
ToyoshimaK.,
FriisR. R.,
VogtP. K.1970; The reproductive and cell-transforming capacities of avian sarcoma virus B77: inactivation with UV light. Virology 42:163–170
VarmusH. E.,
VogtP. K.,
BishopJ. M.1973; Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts. Proceedings of the National Academy of Sciences of the United States of America 70:3067–3071
VarmusH. E.,
GuntakaR. V.,
FanW. J.,
HeasleyS.,
BishopJ. M.1974; Synthesis of viral DNA in the cytoplasm of duck embryo fibroblasts and in enucleated cells after infection by avian sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America 71:3874–3878
VogtP. K.1969; Focus assay of Rous sarcoma virus. In Fundamental Techniques in Virology pp 198–211 Edited by
HabelK.,
SalzmanN. P.
New York: Academic Press;
YoshidaM.,
IkawaY.1977; Induction of some transformation-related properties by a transformation-defective mutant of avian sarcoma virus. Virology 83:444–448
ZarlingD. A.,
MosserA. G.,
TeminH. M.1977; Spontaneous mutations affecting the host range of the B77 strain of avian sarcoma virus involve type-specific changes in the virion envelope antigen. Journal of Virology 21:105–112