1887

Abstract

SUMMARY

The sensitivity of interfering herpes simplex virus (HSV) particles to u.v.-irradiation was studied in a virus stock of HSV-1 strain ANG that contained an excess of interfering over infectious particles. Following u.v.-irradiation, samples of this virus stock were assayed for their plaque-forming capacity and their capacity to interfere with the replication of unirradiated standard virus. Depending on the assay conditions, interfering particles appeared to be less, equally, or more sensitive to u.v. light than infectious particles. It is concluded that interference is a gene function of interfering particles rather than being exerted directly by structural constituents of these particles.

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1979-09-01
2022-01-25
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References

  1. Ben-Porat T., Demarchi J. M., Kaplan A. S. 1974; Characterization of defective interfering viral particles present in a population of pseudorabies virions. Virology 60:29–37
    [Google Scholar]
  2. Bronson D. L., Dreesman G. R., Biswal N., Benyesh-Melnick M. 1973; Defective virions of herpes simplex viruses. Intervirology 1:141–153
    [Google Scholar]
  3. Campbell D. E., Kemp M. C., Perdue M. L., Randall C. C., Gentry G. A. 1976; Equine herpesvirus in vivo: cyclic production of a DNA density variant with repetitive sequences. Virology 69:737–750
    [Google Scholar]
  4. Cleaver J. E., Bootsma D. 1975; Xeroderma pigmentosum: biochemical and genetic characteristics. Annual Review of Genetics 9:19–38
    [Google Scholar]
  5. Darai G., Munk K. 1976; Neoplastic transformation of rat embryo cells with herpes simplex virus. International Journal of Cancer 18:469–481
    [Google Scholar]
  6. Fenwick M. L., Walker M. J. 1968; Suppression of the synthesis of cellular macromolecules by herpes simplex virus. Journal of General Virology 41:37–51
    [Google Scholar]
  7. Fleckenstein B., Bornkamm G. W., Ludwig H. 1975; Repetitive sequences in complete and defective genomes of herpesvirus saimiri. Journal of Virology 15:398–406
    [Google Scholar]
  8. Frenkel N., Jacob R. J., Honess R. W., Hayward G. S., Locker H., Roizman B. 1975; Anatomy of herpes simplex virus DNA. III. Characterization of defective DNA molecules and biological properties of virus populations containing them. Journal of Virology 16:153–167
    [Google Scholar]
  9. Huang A. S. 1973; Defective interfering viruses. Annual Review of Microbiology 27:101–117
    [Google Scholar]
  10. Lytle C. D., Aaronson A., Harvey E. 1972; Host-cell reactivation in mammalian cells. II. Survival of herpes simplex virus and vaccinia virus in normal human and Xeroderma pigmentosum cells. International Journal of Radiation Biology 22:159–165
    [Google Scholar]
  11. Murray B. K., Biswal N., Bookout J. B., Lawford R. E., Courtney R. J., Melnick J. L. 1975; Cyclic appearance of defective interfering particles of herpes simplex virus and the concomitant accumulation of early polypeptide VP 175. Intervirology 5:173–184
    [Google Scholar]
  12. Rabson A. S., Tyrrell S. A., Legallais F. Y. 1969; Growth of ultraviolet-damaged herpesvirus in Xeroderma pigmentosum cells (34312). Proceedings of the Society for Experimental Biology and Medicine 132:802–806
    [Google Scholar]
  13. Russell W. C. 1962; A sensitive and precise plaque assay for herpes virus. Nature, London 195:1028–1029
    [Google Scholar]
  14. Schröder C. H., Stegmann B., Lauppe H. F., Kaerner H. C. 1975/76; An unusual defective genotype derived from herpes simplex virus ANG. Intervirology 6:270–284
    [Google Scholar]
  15. Schröder C. H., Urbaczka G. 1978; Excess of interfering over infectious particles in herpes simplex virus passaged at high m.o.i. and their effect on single-cell survival. Journal of General Virology 41:493–501
    [Google Scholar]
  16. Stegmann B., Zentgraf H., Ott A., Schroder C. H. 1978; Synthesis and packaging of HSV DNA in the course of virus passages at high multiplicity. Intervirology 10:228–240
    [Google Scholar]
  17. Wagner M., Skare J., Summers W. C. 1974; Analysis of defective herpes simplex virus type 1 by restriction endonuclease cleavage and nucleic acid hybridization. Cold Spring Harbor Symposia on Quantitative Biology 39:683–686
    [Google Scholar]
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